Welcome to the Spastic Paraplegia
Foundation, Inc. (SPF)
The SPF is the only organization in the Americas
dedicated exclusively to upper motor neuron disorders called Primary Lateral Sclerosis (PLS) and
Hereditary Spastic Paraplegia* (HSP). We are proud to
take the leadership role on behalf of these conditions.
Not affiliated with any one institution, we are a
charitable, volunteer-driven organization devoted to
supporting research to discover the cures for upper
motor neuron degeneration. Uncovering the riddles to
these processes may also lead to critical findings for
related conditions, such as ALS and spinal cord injury.
Common threads link disorders affecting millions of
The SPF also serves as THE
source of information about these disorders and provides
networking and support programs. We are enormously grateful to our
sponsors, partners and caring community who enable
us to carry out our mission.
Meet some everyday heroes in our community (click on
their photos to read their stories):
We are happy you found us and hope you find what
you are seeking. Please contact us to help support our vision
of the day when all individuals with HSP or PLS are
diagnosed, treated and cured.
* Other names used for HSP:
Familial Spastic Paraparesis (or paraplegia), Spastic
Paraplegia, Strümpell Disease, Hereditary Charcot-Disease,
Spastic Spinal Paralysis, Diplegia Spinalis Progressiva,
French Settlement Disease, Troyer Syndrome, and Silver.