The SPF is the only organization in the Americas dedicated exclusively to upper motor neuron disorders called Primary Lateral Sclerosis (PLS) and Hereditary Spastic Paraplegia* (HSP). We are proud to take the leadership role on behalf of these conditions. See Disorders.

Not affiliated with any one institution, we are a charitable, volunteer-driven organization devoted to supporting research to discover the cures for upper motor neuron degeneration. Uncovering the riddles to these processes may also lead to critical findings for related conditions, such as ALS and spinal cord injury. Common threads link disorders affecting millions of people.

The SPF also serves as THE source of information about these disorders and provides networking and support programs. We are enormously grateful to our sponsors, partners and caring community who enable us to carry out our mission.

Meet some everyday heroes in our community (click on their photos to read their stories):

Nickolas	Geneva	Ken	Flora

We are happy you found us and hope you find what you are seeking. Please contact us to help support our vision of the day when all individuals with HSP or PLS are diagnosed, treated and cured.

* Other names used for HSP: Familial Spastic Paraparesis (or paraplegia), Spastic Paraplegia, Strümpell Disease, Hereditary Charcot-Disease, Spastic Spinal Paralysis, Diplegia Spinalis Progressiva, French Settlement Disease, Troyer Syndrome, and Silver.