Creative BioMolecules, Inc. is a biopharmaceutical company
      focused on the discovery and development of therapies for human tissue regeneration and
      repair. The Company's therapies are based on bone morphogenetic proteins (BMPs) that act
      in initiating and regulating the cellular events involved in the development and repair of
      human tissues and organs.
      Creative BioMolecules' lead product, a bone
      graft substitute, has completed a U.S.  pivotal clinical trial. The bone
      graft substitute is designed to promote new bone growth to heal severe fractures.
      Additional products in development include therapies for kidney
      failure, and stroke and other neurological disorders. The
      Companys research focus is also directed toward the discovery of new therapeutic
      applications of its morphogenic proteins and the understanding of signaling pathways to
      develop small molecules based on the biology of these proteins.
pivotal clinical trial. The bone
      graft substitute is designed to promote new bone growth to heal severe fractures.
      Additional products in development include therapies for kidney
      failure, and stroke and other neurological disorders. The
      Companys research focus is also directed toward the discovery of new therapeutic
      applications of its morphogenic proteins and the understanding of signaling pathways to
      develop small molecules based on the biology of these proteins.
      The Company has a strong portfolio of issued
      patents and patent applications that provides broad protection for product development
      with multiple proteins in many therapeutic fields.