Issued and Maintained US Patents

Creative BioMolecules pursues a policy of obtaining patent protection for patentable subject matter in its proprietary technology.  As of September 25, 1998, the Company owned or had rights to 57 issued patents and 89 pending patent applications in the United States. The Company also owned or had rights to 54 issued foreign patents and 143 foreign patent applications pending in Australia, Canada, Europe, Japan and certain other countries.

A list of Issued and Maintained U.S. Patents is included.

PATENT TITLE PATENT # ISSUE DATE
Adhesive
Synthetic Bioadhesive 5,374,431 20-Dec-94
Synthetic Bioadhesive 5,197,973 30-Mar-93
Single Chain Antibodies
Biosynthetic Binding Proteins for Immunotargeting 5,753,204 19-May-98
Methods and Compositions for High Protein Production from Non-Native DNA 5,733,782 31-Mar-98
Methods and Compositions for High Protein Production from Non-Native DNA 5,658,763 19-Aug-97
Methods and Compositions for High Protein Production from Non-Native DNA 5,631,158 20-May-97
Biosynthetic Binding Proteins for Immunotargeting 5,534,254 09-Jul-96
Serine Rich Peptide Linkers 5,525,491 11-Jun-96
Polypeptide Linkers for Production of Biosynthetic Proteins 5,482,858 09-Jan-96
Biosynthetic Antibody Binding Sites 5,476,786 19-Dec-95
Polypeptide Linkers for Production of Biosynthetic Proteins 5,258,498 02-Nov-93
Biosynthetic Antibody Binding Sites 5,132,405 21-Jul-92
Biosynthetic Antibody Binding Sites 5,091,513 25-Feb-92
Growth Factors
Process for Producing Human Epidermal Growth Factors and Analogs Thereof 4,743,679 10-May-88
Leader Sequence
Leader Sequences for the Production of Recombinant Proteins 5,330,902 19-Jul-94
Recombinant DNA Encoding Amphiphilic Leader Sequence for the Production and Purification of Fusion Proteins 5,302,526 12-Apr-94
Leader Sequences for the Production of Recombinant Proteins 5,215,896 01-Jun-93
Bone Morphogenetic Proteins
Methods for Inducing Endochondral Bone Formation Comprising Administering CDMP-2A, CDMP-2B and/or Variants Thereof 5,814,604 29-Sep-98
Cartilage and Bone-Inducing Proteins 5,750,651 12-May-98
Morphogenic Protein Screening Method 5,741,641 21-Apr-98
Morphogen Treatment of Gastrointestinal Ulcers 5,739,107 14-Apr-98
Morphogen Induced Periodontal Tissue Regeneration 5,733,878 31-Mar-98
Method of Selectively Extracting Osteogenic Protein 5,714,589 03-Feb-98
Methods and Compositions for High Protein Production from Recombinant DNA 5,712,119 27-Jan-98
Method of Diagnosing Renal Tissue Damage or Disease 5,707,810 13-Jan-98
Terminally Sterilized Osteogenic Devices and Preparations Thereof 5,674,292 07-Oct-97
Treatment to Prevent Loss of and/or Increase Bone Mass in Metabolic Bone Diseases 5,674,844 07-Oct-97
Method for Recombinant Production of Osteogenic Protein OP-1 5,670,336 23-Sep-97
Morphogen Induced Periodontal Tissue Regeneration 5,656,593 12-Aug-97
Nucleic Acid Encoding a Novel Morphogenic Protein OP-3 5,652,118 29-Jul-97
OP-3 Induced Morphogenesis 5,652,337 29-Jul-97
Morphogenic Protein Screening Method 5,650,276 22-Jul-97
Synthetic Bone Matrix 5,645,591 08-Jul-97
Lipid Modified Serum Free Media 5,631,159 20-May-97
Methods and Compositions for High Protein Production from Recombinant DNA 5,614,385 25-Mar-97
Compositions and Methods for Identification and Use of Soluble Complex Forms of Osteogenic Proteins 5,610,021 11-Mar-97
Methods and Compositions for High Protein Production from Recombinant DNA 5,585,237 17-Dec-96
Osteogenic Devices 5,496,552 05-Mar-96
Antibodies to Osteogenic Proteins 5,468,845 21-Nov-95
Osteogenic Device 5,354,557 11-Oct-94
Prosthetic Devices Having Enhanced Osteogenic Properties 5,344,654 06-Sep-94
Osteogenic Proteins 5,324,819 28-Jun-94
Osteogenic Proteins 5,266,683 30-Nov-93
Osteogenic Proteins 5,258,494 02-Nov-93
Osteogenic Devices 5,250,302 05-Oct-93
Bone Collagen Matrix for Xenogenic Implants 5,171,574 15-Dec-92
Bone Collagen Matrix for Xenogenic Implants 5,162,114 10-Nov-92
Osteogenic Devices 5,108,753 28-Apr-92
Osteogenic Device 5,011,691 30-Apr-91
Bone Collagen Matrix for Xenogenic Implants 4,975,526 04-Dec-90
Osteogenic Proteins and Polypeptides 4,968,590 06-Nov-90
Oligonucleotide Synthesis
Production of Gene and Protein Analogs through Synthetic Gene Design using Double Stranded Synthetic Oligonucleotides 4,888,286 19-Dec-89
PDGF
Production of Platelet Derived Growth Factor (PDGF) and Mutants Thereof 5,759,815 02-Jun-98
Method for Promoting Tissue Repair and Regeneration Using PDGF and Glucocorticoids 5,376,636 27-Dec-94
Method for Treating Gastrointestinal Ulcers with Platelet Derived Growth Factors (PDGF) 5,234,908 10-Aug-93
Tissue Repair and Regeneration Through the Use of PDGF in Combination with Dexamathasone 5,149,691 22-Sep-92
tPA
Protein Analogues of Tissue Plasminogen Activator 5,700,677 23-Dec-97

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Last modified: November 10, 1998
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