Creative BioMolecules pursues a policy of obtaining patent protection for patentable
subject matter in its proprietary technology. As of September 25, 1998, the Company
owned or had rights to 57 issued patents and 89 pending patent applications in the United
States. The Company also owned or had rights to 54 issued foreign patents and 143 foreign
patent applications pending in Australia, Canada, Europe, Japan and certain other
countries.
A list of Issued and Maintained U.S. Patents is included.
| PATENT
TITLE |
PATENT
# |
ISSUE
DATE |
|
|
|
| Adhesive |
|
|
| Synthetic
Bioadhesive |
5,374,431 |
20-Dec-94 |
| Synthetic
Bioadhesive |
5,197,973 |
30-Mar-93 |
|
|
|
| Single Chain Antibodies |
|
|
| Biosynthetic
Binding Proteins for Immunotargeting |
5,753,204 |
19-May-98 |
| Methods and
Compositions for High Protein Production from Non-Native DNA |
5,733,782 |
31-Mar-98 |
| Methods and
Compositions for High Protein Production from Non-Native DNA |
5,658,763 |
19-Aug-97 |
| Methods and
Compositions for High Protein Production from Non-Native DNA |
5,631,158 |
20-May-97 |
| Biosynthetic
Binding Proteins for Immunotargeting |
5,534,254 |
09-Jul-96 |
| Serine Rich Peptide
Linkers |
5,525,491 |
11-Jun-96 |
| Polypeptide Linkers
for Production of Biosynthetic Proteins |
5,482,858 |
09-Jan-96 |
| Biosynthetic
Antibody Binding Sites |
5,476,786 |
19-Dec-95 |
| Polypeptide Linkers
for Production of Biosynthetic Proteins |
5,258,498 |
02-Nov-93 |
| Biosynthetic
Antibody Binding Sites |
5,132,405 |
21-Jul-92 |
| Biosynthetic
Antibody Binding Sites |
5,091,513 |
25-Feb-92 |
|
|
|
| Growth Factors |
|
|
| Process for
Producing Human Epidermal Growth Factors and Analogs Thereof |
4,743,679 |
10-May-88 |
|
|
|
| Leader Sequence |
|
|
| Leader Sequences
for the Production of Recombinant Proteins |
5,330,902 |
19-Jul-94 |
| Recombinant DNA
Encoding Amphiphilic Leader Sequence for the Production and Purification of Fusion
Proteins |
5,302,526 |
12-Apr-94 |
| Leader Sequences
for the Production of Recombinant Proteins |
5,215,896 |
01-Jun-93 |
|
|
|
| Bone Morphogenetic Proteins |
|
|
| Methods for
Inducing Endochondral Bone Formation Comprising Administering CDMP-2A, CDMP-2B and/or
Variants Thereof |
5,814,604 |
29-Sep-98 |
| Cartilage and
Bone-Inducing Proteins |
5,750,651 |
12-May-98 |
| Morphogenic Protein
Screening Method |
5,741,641 |
21-Apr-98 |
| Morphogen Treatment
of Gastrointestinal Ulcers |
5,739,107 |
14-Apr-98 |
| Morphogen Induced
Periodontal Tissue Regeneration |
5,733,878 |
31-Mar-98 |
| Method of
Selectively Extracting Osteogenic Protein |
5,714,589 |
03-Feb-98 |
| Methods and
Compositions for High Protein Production from Recombinant DNA |
5,712,119 |
27-Jan-98 |
| Method of
Diagnosing Renal Tissue Damage or Disease |
5,707,810 |
13-Jan-98 |
| Terminally
Sterilized Osteogenic Devices and Preparations Thereof |
5,674,292 |
07-Oct-97 |
| Treatment to
Prevent Loss of and/or Increase Bone Mass in Metabolic Bone Diseases |
5,674,844 |
07-Oct-97 |
| Method for
Recombinant Production of Osteogenic Protein OP-1 |
5,670,336 |
23-Sep-97 |
| Morphogen Induced
Periodontal Tissue Regeneration |
5,656,593 |
12-Aug-97 |
| Nucleic Acid
Encoding a Novel Morphogenic Protein OP-3 |
5,652,118 |
29-Jul-97 |
| OP-3 Induced
Morphogenesis |
5,652,337 |
29-Jul-97 |
| Morphogenic Protein
Screening Method |
5,650,276 |
22-Jul-97 |
| Synthetic Bone
Matrix |
5,645,591 |
08-Jul-97 |
| Lipid Modified
Serum Free Media |
5,631,159 |
20-May-97 |
| Methods and
Compositions for High Protein Production from Recombinant DNA |
5,614,385 |
25-Mar-97 |
| Compositions and
Methods for Identification and Use of Soluble Complex Forms of Osteogenic Proteins |
5,610,021 |
11-Mar-97 |
| Methods and
Compositions for High Protein Production from Recombinant DNA |
5,585,237 |
17-Dec-96 |
| Osteogenic Devices |
5,496,552 |
05-Mar-96 |
| Antibodies to
Osteogenic Proteins |
5,468,845 |
21-Nov-95 |
| Osteogenic Device |
5,354,557 |
11-Oct-94 |
| Prosthetic Devices
Having Enhanced Osteogenic Properties |
5,344,654 |
06-Sep-94 |
| Osteogenic Proteins |
5,324,819 |
28-Jun-94 |
| Osteogenic Proteins |
5,266,683 |
30-Nov-93 |
| Osteogenic Proteins |
5,258,494 |
02-Nov-93 |
| Osteogenic Devices |
5,250,302 |
05-Oct-93 |
| Bone Collagen
Matrix for Xenogenic Implants |
5,171,574 |
15-Dec-92 |
| Bone Collagen
Matrix for Xenogenic Implants |
5,162,114 |
10-Nov-92 |
| Osteogenic Devices |
5,108,753 |
28-Apr-92 |
| Osteogenic Device |
5,011,691 |
30-Apr-91 |
| Bone Collagen
Matrix for Xenogenic Implants |
4,975,526 |
04-Dec-90 |
| Osteogenic Proteins
and Polypeptides |
4,968,590 |
06-Nov-90 |
|
|
|
| Oligonucleotide Synthesis |
|
|
| Production of Gene
and Protein Analogs through Synthetic Gene Design using Double Stranded Synthetic
Oligonucleotides |
4,888,286 |
19-Dec-89 |
|
|
|
| PDGF |
|
|
| Production of
Platelet Derived Growth Factor (PDGF) and Mutants Thereof |
5,759,815 |
02-Jun-98 |
| Method for
Promoting Tissue Repair and Regeneration Using PDGF and Glucocorticoids |
5,376,636 |
27-Dec-94 |
| Method for Treating
Gastrointestinal Ulcers with Platelet Derived Growth Factors (PDGF) |
5,234,908 |
10-Aug-93 |
| Tissue Repair and
Regeneration Through the Use of PDGF in Combination with Dexamathasone |
5,149,691 |
22-Sep-92 |
|
|
|
| tPA |
|
|
| Protein Analogues
of Tissue Plasminogen Activator |
5,700,677 |
23-Dec-97 |
