1.    General Review Articles of BMPs

Sakou, T.
Bone morphogenetic proteins: From basic studies to clinical approaches
Bone (United States), V.22/N.6 p. 591-603, 1998
Reddi, A.H.
Role of Morphogenetic Proteins in Skeletal Tissue Engineering and Regeneration
Nature Biotechnology, v.16, p.247-252, 1998
Wozney, JM, Rosen, V.
Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair
Clinical Orthopaedics and Related Research N.346 (Jan), p.26-37, 1998
Vukicevic, S., Latin, V., Chen, P., Batorksy, R., Wozney, J.M.
The bone morphogenetic protein family: multifunctional cellular regulators in the embryo and adult
European Journal of Oral Sciences, V106/1 (Jan), p.160-166, 1998
Ripamonti, U., Duneas, N.
Tissue morphogenesis and regeneration by bone morphogenetic proteins
Plastic and Reconstructive Surgery, V.101/N1 (Jan), p.227-239, 1998
Roelen, B.A.J., Goumans, M.J., VanRooijen, M.A., Mummery, C.L.
Differential expression of BMP receptors in early mouse development
International Journal of Developmental Biology, V41, N4, p541-549, Aug, 1997.
Rosen, V., Cox, K., Hattersley, G.
Bone Morphogenetic Proteins
Principles of Bone Biology, Chapter 47, pp. 661-671, (book) 1996
Yamashita, H., Tendijke, P., Heldin, C.H., Miyazono, K.
Bone morphogenetic protein receptors
Bone, V19, N6, p569-574, December, 1996
Rosen, V., Thies, R.S., Lyons, K.
Signaling Pathways in Skeletal Formation: A Role for BMP Receptors
Ann NY Acad Sci V785 p59-69, 1996
Karsenty, G., Luo, G., Hofmann, C., Bradley, A.
BMP-7 is Required for Nephrogenesis, Eye Development, and Skeletal Patterning
Ann NY Acad Sci V785 p98-107, 1996
King, J.A., Storm, E.E., Marker, P.C., Dileone, R.J., Kingsley, D.M.
The Role of BMPs and GDFs in Development of Region-specific Skeletal Structures
Ann NY Acad Sci V785 p70-79, 1996
Linkhard, T.A., Subburaman, M. and Baylink D.J.
Growth Factors for Bone Growth and Repair: IGF, TGF-B and BMP
Bone V19, No. 1 Supplement, p1S-12S, July 1996
Hogan, B.L.M.
Bone Morphogenetic Proteins: Multifunctional Regulators of Vertebrate Development
Genes & Development V10, p1580-1594, 1996
Massague, J.
TGF-B Signaling: Receptors, Transducers, and Mad Proteins
Cell V85 p947-950, June 28, 1996
Cook, S.D., and Rueger, D.C.
Osteogenic Protein-1: Biology and Applications
Clin Orthop (324) p29-38, March 1996
Rudkin, G.H., and Miller, T.A.
Growth-Factors in Surgery
Plastic and Reconstructive Surgery V97 (2) p469-476, February 1996
Ripamonti, U., Reddi, A.H.
Bone Morphogenetic Proteins: Applications in Plastic and Reconstructive Surgery
Advances in Plastic & Reconstructive Surgery, v.11, pp. 47-73, 1995
Vukicevic, S., Stavljenic, A., and Pecina, M.
Discovery and Clinical Applications of Bone Morphogenetic Proteins
European Journal of Clinical Chemistry and Clinical Biochemistry V33 (10) p661-671, October 1995
Kirkerhead, C.A.
Recombinant Bone Morphogenetic Proteins - Novel Substances for Enhancing Bone Healing
Veterinary Surgery V24 (5) p408-419 September-October 1995
Ripamonti, U., and Vukicevic, S.
Bone Morphogenetic Proteins - from Developmental Biology to Molecular Therapeutics
South African Journal of Science V91 (6) p277-280, June 1995
Einhorn, T.A.
Current Concepts Review Enhancement of Fracture-healing
The Journal of Bone and Joint surgery, V77-A (6), p.940-956, June 1995
Wozney, J.M.
The Potential Role of Bone Morphogenetic Proteins in Periodontal Reconstruction
J of Periodontology V66 (6) p506-510, June 1995
Einhorn, T.A.
Enhancement of Fracture-healing
J of Bone and Joint Surgery (American) V077A (6) p940-956, June 1995
Reddi, A.H.
Bone Morphogenetic Proteins, Bone Marrow Stromal Cells, and Mesenchymal Stem Cells
Clinical Orthopaedics and Related Research, N313, p115-119, 1995
Sampath, T.K., and Rueger, D.C.
Structure, Function, and Orthopedic Applications of Osteogenic Protein-1 (OP-1)
Complications in Orthopedics p101-107, Winter 1994
Alper, J.
Biomedicine - Boning Up - Newly Isolated Proteins Heal Bad Breaks
Science V263 (5145) p324-325, January 21, 1994
Ripamonti, U., and Reddi, A.H.
Periodontal Regeneration - Potential Role of Bone Morphogenetic
J of Periodontal Research V29 (4) p225-235, July 1994
Wolfe, M.W., and Cook, S.D.
Use of Osteoinductive Implants in the Treatment of Bone Defects
Med Prog Technol (US) V20 (3-4) p155-168, 1994
Kingsley, D.M.
What do BMPs do in Mammals - Clues from the Mouse Short Ear Mutation
Trends in Genetics V10 (1) p 16-21, 1994
Reddi, A.H., and Cunningham, N.S.
Initiation and Promotion of Bone Differentiation by Bone Morphogenetic Proteins
J Bone Miner Res (US) V8 (S2) pS499-S502, December 1993
Kenley, R.A., Yim, K., Abrams, J., Ron, E., Turek, T., Marden, L.J., and Hollinger, J.O.
Biotechnology and Bone-graft Substitutes
Pharmaceutical Research V10 (10) p1393-1401, October 1993
Elima, K.
Osteoinductive Proteins
Annals of Medicine V25 (4) p395-402, August 1993
Baylink, D.J., Finkelman, R.D., and Mohan S.
Growth-Factors to Stimulate Bone-formation
J of Bone and Miner Res V8 (S2) pS565-S572, December 1993
Wang, E.A.
Bone Morphogenetic Proteins (BMPs) - Therapeutic Potential in Healing Bony Defects
Trends in Biotechnology V11 (9) p379-383, September 1993
Wozney, J.M.
The Bone Morphogenetic Protein Family and Osteogenesis
Mol Reprod Dev V32 (2) p160-167, June 1992
Lyons, K.M., Jones, C.M., and Hogan, B.L.
The DVR Gene Family in Embryonic Development
Trends Genet (England) V7 (11-12) p408-412, November - December 1991
Wozney, J.M., Rosen, V., Byrne, M., Celeste, A.J., Moutsatsos, I., and Wang, E.A.
Growth Factors Influencing Bone Development
J Cell Sci Suppl (England) V13 p149-156, 1990
Wozney, J.M.
Bone Morphogenetic Proteins
Prog Growth Factor Res (England) V1 (4) p267-280, 1989

2.   Molecular Biology and Biochemistry of BMPs

Amthor, H., Christ, B., Weil, M., Patel, K.
The importance of timing differentiation during limb muscle development
Current Biology V.8/N.11 p. 642-652, 1998
Onishi, T., Ishidou, Y., Nagamine, T., Yone, K., Imamura, T., Kato, M., Sampath, T.K., Ten Dijke, P., Sakou, T.
Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats
Bone (United States) V.22/N.6, p. 605-612, 1998
Ericson, J., Norlin, S., Jessell, T.M., Edlund, T.
Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary
Development (United Kingdom), V.125/N.6, p. 1005-1015, 1998
Takase, M., Imamura, T., Sampath, T.K., Takeda, K., Ichijo, H., Miyazono, K., Kawabata, M.
Induction of Smad6 mRNA by bone morphogenetic proteins
Biochemical and BioPhysical Research Communications, v.244(1), p.26-29, 1998
Nakamura, T., Aikawa, T., Iwamoto-Enomoto, M., Iwamoto, M., Higuchi, Y., Maurizio, P., Kinto, N., Yamaguchi, A., Noji, S., Kurisu, K., Matsuya, T.
Induction of Osteogenic Differentiation by Hedgehog Proteins
Biochemical & Biophysical Research Communications, v.237, pp. 465-469, 1997
Suzuki, A., Kaneko, E., Maeda, J., Ueno, N.
Mesoderm Induction by BMP-4 and -7 Heterodimers
Biochemical & Biophysical Research Communications, v. 232, pp. 153-156, 1997
Wang, S., Krinks, M., Kleinwaks, L., Moos, M.
A novel Xenopus homolog of bone morphogenetic protein-7 (BMP-7)
Genes Funct. V1(4), p.259-271, 1997
Harada, S.I., Sampath, T.K., Augin, J.E., Rodan, G.A.
Osteogenic protein-1 up-regulation of the collagen X promoter activity is mediated by a MEF-2 like sequence and requires an adjacent AP-1 sequence
Molecular Endocrinology 11 (12) p1832-1845. 1997
Piek, E., Franzen, P. Heldin, C-H, Ten Dijke, P.
Characterization of a 60-kDa cell surface-associated transforming growth factor-beta binding protein that can interfere with transforming growth factor-beta receptor binding
Journal of Cellular Physiology 173 (3). p447-459. 1997
Namiki, M., Akiyama, S., Katagiri, T., Suzuki, A., Ueno, N., Yamaji, N., Rosen, V., Wozney, J.M., Suda, T.
A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2 induced signal transduction in C2C12 myoblasts
Journal of Biological Chemistry, V272, N35, p22046-22052, Aug.1997
Hayashi, K., Ishidou, Y., Yonemori, K., Nagamine, T., Origuchi, N., Maeda, S., Imamura, T., Kato, M., Yoshida, H., Sampath, T.K., ten Dijke, P., Sakou, T.
Expression and localization of bone morphogenetic proteins (BMPs) and BMP receptors in ossification of the ligamentum flavum
Bone (US) 21 (1), p23-30, July 1997
Ethier, J.F., Lussier, J.G., Silversides, D.W.
Bovine activin receptor type IIB messenger ribonucleic acid displays alternative splicing involving a sequence homologous to Src-hmology 3 domain binding sites
Endocrinology, V138, N6, p2425-2434, June, 1997
Beppu, H., Minowa, O., Miyazono, K., Kawabata, M.
cDNA cloning and genomic organization of the mouse BMP type II receptor
Biochemical and Biophysical Research Communications, V235, N3 , p499-504, June 27, 1997
Koyama, H.
Analysis of genes implicated in osteogenic signaling by osteogenic protein-1 (OP-1) using differential display method
Kokubyo Gakkai Zasshi (Japan) 64 (2) p205-22, , June, 1997
Suzuki, A., Kaneko, E., Ueno, N., Hemmati-Brivanlou, A.
Regulation of epidermal induction by BMP2 and BMP7 signaling
Dev Biol (US) 189 (1) P112-22, Sept. 1997
Yonemori, K., Imamura, T., Ishidou, Y., Okano, T., Matsunaga, S., Yoshida, H., Kato, M., Sampath, T.K., Miyazono, K., ten Dijke, P., Sakou, T.
Bone Morphogenetic Protein Receptors and Activin Receptors are Highly Expressed in Ossified Ligament Tissues of Patients with Ossification of the Posterior Longitudinal Ligament
American Journal of Pathology V150 N4 p1335-1347, April 1997
Buscher, D., Bosse, B., Heymer, J., Ruther, U.
Evidence for genetic control of Sonic hedgehog by Gil3 in mouse limb development
Mech Dev (Ireland) 62 (2) p175-82, March, 1997
Dudley, A.T., Robertson, E.J.
Overlapping Expression Domains of Bone Morphogenetic Protein Family Members Potentially Account for Limited Tissue Defects in BMP-7 Deficient Embryos
Developmental Dynamics V208 N3 p349-362, March 1997
Macias, D., Ganan, Y., Sampath, T.K., Piedra, M.E., Ros M.A., Hurie, J.M.
Role of BMP-2 and OP-1 (BMP-7) in Programmed Cell Death and Skeletogenesis during Chick Limb Development
Development V124 N6 p1109-1117, March 1997
Feuerbach, D., Loetscher, E., Buerki, K., Sampath, T.K., Feyen, J.H.M.
Establishment and Characterization of Conditionally Immortalized Stromal Cell Lines from a Temperature-Sensitive T-Ag Transgenic Mouse
Journal of Bone and Mineral Research V12(2) p179-190, 1997
Jena, N., Martin-Seisdedos, C., McCue, P., Croce, C.M.
BMP-7 Null Mutation in Mice: Developmental Defects in Skeleton, Kidney, and Eye
Exp Cell Res (United States) V230 (1) p28-37, January 10, 1997
Israel, D.I., Nove, J., Kerns, K.M., Kaufman, R.J., Rosin, V., Cox, K.A., Wozney, J.M.
Heterodimeric Bone Morphogenetic Proteins Show Enhanced Activity In Vitro and In Vivo
Growth Factors (Switzerland) V13 (3-4) p291-300, 1996
Hofmann, C., Luo, G.B., Balling, R., Karsenty, G.
Analysis of Limb Patterning in BMP-7-Deficient Mice
Dev Genetics V19 N1 p43-50, 1996
Harada, S., Sampath, T.K., Rodan, G.A.
Identification of an AP-1 like Response Region for Osteogenic Protein-1 in Type X Collagen Promoter
Annals of the NY Acad Sci V785 p259-260, 1996
Griffith, D.L., Keck, P.C., Sampath, T.K., Rueger, D.C., and Carlson, W.D.
Three-dimensional Structure of Recombinant Human Osteogenic Protein 1: Structural Paradigm for the Transforming Growth Factor Beta Superfamily
Proc Natl Acad Sci US V93 (2) p878-883, January 23, 1996
Wall, N.A., and Hogan, B.L.M.
Expression of Bone Morphogenetic Protein-4 (BMP-4), Bone Morphogenetic Protein-7 (BMP-7), Fibroblast Growth Factor-8 (FGF-8) and Sonic Hedgehog (SHH) During Branchial Arch Development in the Chick
Mechanisms of Development V53 (3) p383-392, 1995
Ishidou, Y., Kitajima, I., Obama, H., Maruyama, I., Murata, F., Imamura, T., Yamada, N., ten Dijke, P., Miyazono, K., and Sakou, T.
Enhanced Expression of Type I Receptors for Bone Morphogenetic Proteins During Bone Formation
Journal of Bone and Mineral Research V10 (11) p1651-1659, November 1995
Luo, G., Hofmann, C., Bronckers, A.L.J., Sohocki, M., Bradley, A., and Karsenty, G.
BMP-7 is an Inducer of Nephrogenesis, and is also Required for Eye Development and Skeletal Patterning
Genes & Development V9 (22) p2808-2820, November 15, 1995
Dudley, A.T., Lyons, K.M., Robertson, E.J.
A Requirement for Bone Morphogenetic Protein-7 During Development of the Mammalian Kidney and Eye
Genes & Development V9 (22) p2795-2807, November 15, 1995
Kitten, A.M., Lee, J.C., and Olson, M.S.
Osteogenic Protein-1 Enhances Phenotypic Expression in ROS 17/2.8 Cells
Am J Physiol V269 (5 Pt 1) pE918-E926, November 1995
Rosenzweig, B.L., Imamura, T., Okadome, T., Cox, G.N., Yamashita, H., ten Dijke, P., Heldin, C.H., and Miyazono, K.
Cloning and Characterization of a Human Type II Receptor for Bone Morphogenetic Proteins
Proc Natl Acad Sci U S A (US) V92 (17) p7632-7636, August 15, 1995
Marker, PC., King, J.A., Copeland, N.G., Jenkins, N.A., and Kingsley, D.M.
Chromosomal Localization, Embryonic Expression, and Imprinting Tests for BMP-7 on Distal Mouse Chromosome 2
Genomics V28 (3) p576-580, August 10, 1995
Yamashita, H., ten Dijke, P., Huylebroeck, D., Sampath, T.K., Andries, M., Smith, J.C., Heldin, C.H., and Miyazono, K.
Osteogenic Protein-1 Binds to Activin Type II Receptors and Induces Certain Activin-like Effects
J Cell Bio (US) V130 (1) p217-226, July 1995
Liu, F., Ventura, F., Doody, J., and Massague, J.
Human Type II Receptor for Bone Morphogenic Proteins (BMPs) Extension of the Two-kinase Receptor Model to the BMPs
Mol Cell Biol V15(7) p3479-3486, July 1995
Dewulf, N., Verschueren, K., Lonnoy, O., Moren, A., Grimsby, S., Vande Spiegle, K., Miyazono, K., Huylebroeck, D., ten Dijke, P.
Distinct Spatial and Temporal Expression Patterns of Two Type I Receptors for Bone Morphogenetic Proteins During Mouse Embryogenesis
Endocrinology (US) V136 (6) p2652-2663, June 1995
Lyons, K.M., Hogan, B.L., and Robertson, E.J.
Colocalization of BMP 7 and BMP 2 RNAs Suggests that these Factors Cooperatively Mediate Tissue Interactions During Murine Development
Mech Dev (Ireland) V50 (1) p71-83, March 1995
Helder, M.N., Ozkaynak, E., Sampath, K.T., Luyten, F.P., Latin, V., Oppermann, H., and Vukicevic, S.
Expression Pattern of Osteogenic Protein-1 (Bone Morphogenetic Protein-7) in Human and Mouse Development
Journal of Histochemistry and Cytochemistry V45 (10) p1035-1044, 1995
Houston, B., Thorp, B.H., and Burt D.W.
Molecular Cloning and Expression of Bone Morphogenetic Protein-7 in the Chick Epiphyseal Growth Plate
Journal of Molecular Endocrinology V13 (3) p289-301, December 1994
Griffith, D.L., Oppermann, H., Rueger, D.C., Sampath, T.K., Tucker, R.F., and Carlson, W.D.
Crystallization and Preliminary Crystallographic Data of Recombinant Human Osteogenic Protein-1
J Mol Biol (ENGLAND) V244 (5) p657-658, December 16, 1994
Postlethwaite, A.E., Raghow ,R., Stricklin, G., Ballou, L., and Sampath, T.K.
Osteogenic Protein-1, a Bone Morphogenic Protein Member of the TGF-beta Superfamily, Shares Chemotactic But Not Fibrogenic Properties with TGF-beta
J Cell Physiol (US) V161 (3) p562-570, December 1994
ten Dijke, P., Yamashita, H., Sampath, T.K., Reddi, A.H., Estevez, M., Riddle, D.L., Ichijo, H., Heldin, C.H., and Miyazono, K.
Identification of Type I Receptors for Osteogenic Protein-1 and Bone Morphogenetic Protein-4
J Biol Chem V269 (25) p16985-16988, June 1994
Jones, W.K., Richmond, E.A., White, K., Sasak, H., Kusmik, W., Smart, J., Oppermann, H., Rueger, D.C., and Tucker, R.F.
Osteogenic Protein-1 (OP-1) Expression and Processing in Chinese Hamster Ovary Cells: Isolation of a Soluble Complex Containing the Mature and Pro-domains of OP-1
Growth Factors (Switzerland) V11 (3) p215-225, 1994
Maliakal ,J.C., Asahina, I., Hauschka, P.V., and Sampath, T.K.
Osteogenic Protein-1 (BMP-7) Inhibits Cell Proliferation and Stimulates the Expression of Markers Characteristic of Osteoblast Phenotype in Rat Osteosarcoma
Growth Factors (SWITZERLAND) V11 (3) p227-34, 1994
Vukicevic, S., Latin, V., Chen, P., Batorksy, R., Reddi, A.H., and Sampath, T.K.
Localization of Osteogenic Protein-1 (Bone Morphogenetic Protein-7) During Human Embryonic Development - High Affinity Binding to Basement Membranes
Biochemical and Biophysical Research Communications V198 (2) p693-700, January 28, 1994
Sodek, J., Li, I.W.S., Li, H., Bellows, C.G., McCulloch, C.A.G., Tenebaum, H.C., Ellen, R.P.
The Role of TGF-beta and BMP-7 in Regenerating Bone and Soft Tissues
Mater Sci Eng V2 (1-2) p19-26, 1994
Suzuki, A., Nishimatsu, S., Murakami, K., and Ueno, N.
Differential Expression of Xenopus BMPs in Early Embryos and Tissues
Zoolog Sci (JAPAN), V10 (1) p175-178, February 1993
Sampath, T.K., Rashka, K.E., Doctor, J.S., Tucker, R.F., and Hoffman, F.M.
Drosophilia Transforming Growth Factor B Superfamily Proteins Induce Endochondral Bone Formation in Mammals
Proc Natl Acad Sci (UNITED STATES) V90 p6004-6008, July 1993
Nishimatsu, S., Suzuki, A., Shoda, A., Murakami, K., and Ueno, N.
Genes for Bone Morphogenetic Proteins are Differentially Transcribed in Early Amphibian Embryos
Biochem Biophys Res Commun V186 (3) p1487-1495, 1992
Hahn, G.V., Cohen, R.B., Wozney, J.M., Levitz, C.L., Shore, E.M., Zasloff, A., Kaplan, S.
A Bone Morphogenetic Protein Subfamily: Chromosome Localization of Human Genes for BMP-5, BMP-6, and BMP-7
Genomics V14 (3) p759-762, 1992
÷zkaynack, E., Schnegelsberg, P.N.., Jin, D.F., Clifford, G.M., Warren, F.D., Drier, E.A., and Oppermann, H.
Osteogenic Protein-2 a New Member of the Transforming Growth Factor-Beta Superfamily Expressed Early in Embryogenesis
J Biol Chem V267 (35) p220-227, December 15, 1992
Sampath, T.K., Maliakal, J.C., Hauschka, P.V., Jones, W.K., Sasak, H., Tucker R.F., White, K.H., Coughlin, J.E., Tucker, M.M., Pang, R., Corbett, C., Ozkaynak, E., Oppermann, H., Rueger, D.C.
Recombinant Human Osteogenic Protein-1 (hOP-1) Induces New Bone Formation In Vivo with a Specific Activity Comparable with Natural Bovine Osteogenic Protein and Stimulates Osteoblast Proliferation and Differentiation In Vitro
J Biol Chem V267 (28) p20352-20362, 1992
÷zkaynack, E., Schnegelsberg, P.N., and Oppermann ,H.
Murine Osteogenic Protein (OP-1): High Levels of mRNA in Kidney
Biochem Biophys Res Commun V179 (1) p116-123, August 30, 1991
Celeste, A.J., Ainnazzi, J.A., Taylor, R.C., Hewick, R.M., Rosen, V., Wang, E.A., and Wozney, J.M.
Identification of Transforming Growth Factor Beta Family Members Present in Bone-inductive Protein Purified from Bovine Bone
Proc Natl Acad Sci USA (US) , V87 (24) p9843-9847, December 1990
Sampath, T.K., Coughlin, J.E., Whetstone, R.M., Banach, D., Corbett, C., Ridge R.J., Ozkaynak, E., Oppermann, H., Rueger, D.C.
Bovine Osteogenic Protein is Composed of Dimers Of OP-1 And BMP-2A, Two Members of The Transforming Growth Factor-beta Superfamily
J Biol Chem V265 (22) p13198-13205, August 5, 1990
÷zkaynack, E., Rueger, D.C., Drier, E.A., Corbett, C., Ridge, R.J., Sampath, T.K., and Oppermann, H.
OP-1 cDNA Encodes an Osteogenic Protein in the TGF-beta Family
EMBO J (England) V9 (7) p2085-2093, July 1990
Sampath, T.K., and Reddi, A.H.
Homology of Bone-Inductive Proteins from Human, Monkey, Bovine, and Rat Extracellular Matrix
Proc Natl Acad Sci V80, p6591-6595, November 1983
Sampath, T.K., Reddi, R.H.
Disassociative Extraction and Reconstitution of Extracellular Matrix Components Involved in Local Bone Differentiation
Proc Natl Acad Sci US V78 (12) p7599-7603, December 1981

3.   Orthopaedic Reconstruction

Grimsrud, C.D., Rosier, R.N., Puzas, J.E., Reynolds, P.R., Reynolds, S.D., Hicks, D.G., O’Keefe, R.J.
Bone morphogenetic protein-7 in growth-plate chondrocytes: Regulation by retinoic acid is dependent on the stage of chondrocyte mutation
Journal of Orthopaedic Research (United States) V.16/N.2, p.247-255, 1998
Terkeltaub, R.A., Johnson, K., Rohnow, D., Goomer, R., Burton, D., Deftos, L.J.
Bone morphogenetic proteins and bFGF exert opposing regulatory effects on PTHrP expression and inorganic pyrophosphate elaboration in immortalized murine endochondral hypertrophic chondrocytes (MCT cells)
Journal of Bone and Mineral Research (United States), V.13/N.6, p. 931-941, 1998
Zohar, R., McCulloch, CAG, Sampath K., Sodek, J.
Flow cytometric analysis of recombinant human osteogenic protein-1 (BMP-7) responsive subpopulations from fetal rat calvaria based on intracellular osteopontin content
Matrix Biology (Germany), V16/6, p.295-306, 1998
Yeh, L.C.C., Adamo, M.L., Duan, C., Lee, J.C.
Osteogenic protein-1 regulates insulin-like growth factor-I (IGF-I), IGF-II, and IGF-binding protein-5 (IGFBP-5) gene expression in fetal rat calvaria cells by different mechansims
Journal of Cellular Physiology, V.175/N.1, p. 78-88, 1998
Erlacher, L., McCartney, J., Piek, E., Dijke, P.T., Yanagishita, M., Oppermann, H., Luyten, F.P.
Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis
Journal of Bone and Mineral Research (United States), 13/3, p. 383-392, 1998
Klein-Nulend, J., Louwerse, R.T., Heyligers, I.C., Wuisman, P.I.J.M., Semeins, C.M., Goei, S.W., Burger, E.H.
Osteogenic protein (OP-1, BMP-7) stimulates cartilage differentiation of human and goat perichondrium tissue in vitro
Journal of Biomedical Materials Research 40 (4), p. 614-620, 1998
Erlacher, L., Ng, CK, Ullrich, R., Krieger, S., Luyten, FP
Presence of cartilage-derived morphogenetic proteins in articular cartilage and enhancement of matrix replacement in vitro
Arthritis and Rheumatism, V.41/N2 (Feb), p.263-273, 1998
Grgic, M., Jelic, M., Basic, V., Basic, N., Pecina, M., Vukicevic, S.
Regeneration of articular cartilage defects in rabbits by osteogenic protein-1 (bone morphogenetic protein-7)
Acta Medica Croatica, V51 (1), p23-27, 1997
Haaijman, A., D’Souza, RN, Bronckers, AL, Goei, SW, Burger EH
OP-1 (BMP-7) affects mRNA expression of type I, II, X collagen, and matrix Gla protein in ossifying long bones in vitro
J. Bone Miner Res (U.S.), V12(11), p.1815-23, 1997
Huch, K., Wilbrink, B., Flechtenmacher, J., Koepp, H.E., Aydelotte, M.B., Sampath, T.K., Kuettner, K.E., Mollenhauer, J., Thonar, E.J, Thomar, M.A.
Effects of recombinant human osteogenic protein 1 on the production of proteoglycan, prostaglandin E2, and interleukin-1 receptor and antagonist by human articular chondrocytes cultured in the presence of interleukin-1
Arthritis Rheum (UNITED STATES), 1997, 40 (12) p2157-61
Wu, L.N.Y., Ishikawa, Y., Genge, B.R., Sampath, T.K., Wuthier, R.E.
Effect of osteogenic protein-1 on the development and mineralization primary cultures of avian growth plate chondrocytes: Modulation by retinoic acid
Journal of Cellular Biochemistry 67 (4). 1997. 498-513
Kitten, A., Harvey, S., Criscimagna, N., Asher, M., Lee, J.C., Olson, M.S.
Osteogenic protein-1 downregulates endothelin A receptors in primary rat osteoblasts
Am. J. Physiol, V272, N6, pE967-E975, 1997
Yeh, L.C.C., Adamo, M.L., Olson, M.S., Lee, J.C.
Osteogenic protein-1 and insulin-like growth factor I synergistically stimulate rat osteoblastic cell differentiation and proliferation
Endocrinology, V138, N10, p4181-4190, October 1997
Hayden, J.M., Strong, d.D., Baylink, D.J., Powell, D.R., Sampath, T.K., Mohan, S.
Osteogenic Protein-1 stimulates production of insulin-like growth factor binding protein-3 nuclear transcripts in human osteosarcoma cells
Endocrinology, V138, N10, p4240-4247, October, 1997
Srinivasan, N., Baylink, D.J., Sampath, K., Mohan, S.
Effects of inhibitors of signal transduction pathways on transforming growth factor beta 1 and osteogenic protein-1 induced insulinlike growth factor binding protein-3 expression in human bone cells
Journal of Cellular Physiology, V173, N1, p28-35, Oct, 1997
Ripamonti, U., Duneas, N., VandenHeever, B., Bosch, C., Crooks, J.
Recombinant transforming growth factor-beta 1 induces endochondral bone in the baboon and synergizes with recombinant osteogenic protein-1 (bone morphogenetic protein-7) to initiate rapid bone formation
Journal of Bone and Mineral Research, V12 (10), p1584-1595, October, 1997
Lietman, S.A., Yanagishita, M., Sampath, T.K., Reddi, A.H.
Stimulation of proteoglycan synthesis in explants of porcine articular cartilage by recombinant osteogenic protein-1 (bone morphogenetic protein-7)
J Bone Joint Surg Am (UNITED STATES) 79 (8) p1132-7, Aug, 1997
Honda, Y., Knutsen, R., Strong, D.D., Sampath, T.K., Baylink, D.J., Mohan, S.
Osteogenic Protein-1 Stimulates mRNA Levels of BMP-6 and Decreases mRNA Levels of BMP-2 and -4 in Human Osteosarcoma Cells
Calcified Tissue International V60 N3 p297-301, March 1997
Renier, M.L., Kohn, D.H.
Development and Characterization of a Biodegradable Polyphosphate
Journal of Biomedical Materials Reearch, V34, N1, P95-104, Jan. 1997
Ripamonti, U., Van Den Heever, B., Sampath, T.K., Tucker, M.M., Rueger, D.C., Reddi, A.H.
Complete Regeneration of Bone in the Baboon by Recombinant Human Osteogenic Protein-1 (hOP-1, Bone Morphogenetic Protein-7)
Growth Factors V13 p273-289, 1996
Cheifetz, S., Li, I..W.S., McCulloch, C.A.G., Sampath, K., Sodek, J.
Influence of Osteogenic Protein-1 (OP-1, BMP-7) and Transforming Growth Factor- 1 on Bone Formation In Vitro
Connect Tissue Res V35 (1-4) p71-78, 1996
Grgic, M.
The Effect of Osteogenic Protein-1 (Bone Morphogenetic Protein-7) on Growth in Long Bones in Rats
Lijec Vjesn (CROATIA)V118(9) p191-4, September 1996
Yeh L-C C., Adamo, M.L., Kitten, A.M., Olson, M.S., and Lee, J.C.
Osteogenic Protein-1-Mediated Insulin-like Growth Factor Gene Expression in Primary Cultures of Rat Osteoblastic Cells
Endocrinology (US) V137 (5) p1921-1931, May 1996
Mayer, H., Scutt, A.M., and Ankenbauer, T.
Subtle Differences in the Mitogenic Effects of Recombinant Human Bone Morphogenetic Protein-2 to Protein-7 on DNA-Synthesis on Primary Bone-Forming Cells and Identification of BMP-2/4 Receptor
Calcified Tissue International V58 (4) p249-255, April 1996
Dee, K.C., Rueger, D.C., Andersen, T.T., and Bizios, R.
Conditions which Promote Mineralization at the Bone-implant Interface - a Model In-vitro Study
Biomaterials V17 (2) p209-215, January 1996
Asahina, I., Sampath, T.K., and Hauschka P.V.
Human Osteogenic Protein-1 Induces Chondroblastic, Osteoblastic, and/or Adipocytic Differentiation of Clonal Murine Target Cells
Exp Cell Res V222 (1) p38-47, January 10, 1996
Wall, N.A. and Hogan, B.L.
Expression of Bone Morphogenetic Protein-4 (BMP-4), Bone Morphogenetic Protein-7 (BMP-7), Fibroblast Growth Factor-8 (FGF-8) and Sonic Hedghog (SHH) During Branchial Arch Development in the Chick
Mech Dev (IRELAND), V53 (3), p383-92, November 1995
Mohan, S., Libanati, C., Dony, C., Lang, K., Srinivasan, N., and Baylink, D.J.
Development, Validation, and Application of Radioimmunoassay for Insulin-like Growth Factor Binding Protein-5 in Human Serum and Other Biological Fluids
J Clin Endocrinol Metab United States V80 (9) p2638-2645, September 1995
Kanzaki ,S., Baxter, R.C., Knutsen, R., Baylink ,D.J., and Mohan, S.
Evidence that Human Bone Cells in Culture Secrete Insulin-like Growth Factor (IGF)-II and IGF Binding Protein-3 but not Acid-labile Subunit Both Under Basal and Regulated Conditions
J Bone Mineral Research (US), V10 (6) p854-858, June 1995
Cook, S.D., Wolfe, M.W., Salkeld, S.L., and Rueger, D.C.
Effect of Recombinant Human Osteogenic Protein-1 on Healing of Segmental Defects in Non-human Primates
J Bone Joint Surg Am (US) V77 (5) p734-750, May 1995
Sodek, J., Chen, J., Nagata, T., Kasugai, S., Todescan, R. Jr., Li, I.W., and Kim, R.H.
Regulation of Osteopontin Expression in Osteoblasts
Ann NY Acad Sci V760 p223-241, April 21, 1995
Hentunen, T.A., Lakkakorpi, P.T., Tuukkanen, J., Lehenkari, P.P., Sampath, T.K., and Vaananen, H.K.
Effects of Recombinant Human Osteogenic Protein-1 on the Differentiation of Osteoclast-like Cells and Bone Resorption
Biochem Biophys Res Commun (US) V209 (2) p433-443, April 17, 1995
Knutsen, R., Honda, Y., Strong, D.D., Sampath, T.K., Baylink, D.J., and Mohan, S.
Regulation of Insulin-like Growth Factor System Components by Osteogenic Protein-1 in Human Bone Cells
Endocrinology (US) V136 (3) p857-865, March 1995
Chen, P., Vukicevic, S., Sampath, T.K., and Luyten , F.P.
Osteogenic Protein-1 Promotes Growth and Maturation of Chick Sternal Chondrocytes in Serum-free Cultures
J Cell Sci (ENGLAND) V108 (Pt 1) p105-114, January 1995
Aono, A., Hazama, M., Notoya, K., Taketomi, S., Yamasaki, H., Tsukuda, R., Sasaki, S., and Fujisawa, Y.
Potent Ectopic Bone-inducing Activity of Bone Morphogenetic Protein-4/7 Heterodimer
Biochem Biophys Res Commun V210 (3) p670-677, 1995
Cook, S.D., Dalton, J.E., Tan, E.H., Whitecloud, T.S. III, and Rueger D.C.
In Vivo Evaluation of Recombinant Human Osteogenic Protein (rhOP-1) Implants As A Bone Graft Substitute for Spinal Fusions
Spine V19 (15) p1655-1663, 1994
Malpe, R., Baylink, D.J., Sampath, T.K., and Mohan, S.
Evidence That Human Bone Cells in Culture Contain Binding Sites for Osteogenic Protein-1
Biochem Biophys Res Commun V201(2) p1140-1147, June 30, 1994
Dieudonne, S.C., Semeins, C.M., Goei, S.W., Vukicevic, S., Nulend, J.K., Sampath, T.K., Helder, M., and Burger, E.H.
Opposite Effects of Osteogenic Protein And Transforming Growth Factor Beta On Chondrogenesis In Cultured Long Bone Rudiments
Journal of Bone and Mineral Research V9 (6) p771-780, June 1994
Cook, S.D., Baffes, G.C., Wolfe, M.W., Sampath, T.K., Rueger, D.C., and Whitecloud, T.S. III
The Effect of Recombinant Human Osteogenic Protein-1 on Healing of Large Segmental Bone Defects
J Bone Joint Surg Am V76 (6) p827-828, June 1994
Cook, S.D., Baffes, G.C., Wolfe, M.W., Sampath, T.K., and Rueger, D.C.
Recombinant Human Bone Morphogenetic Protein-7 Induces Healing in a Canine Long-bone Segmental Defect Model
Clin Orthop V30, p302-312, April 1994
Chen, P., Vukicevic, S., Sampath, T.K., and Luyten, F.P.
Bovine Articular Chondrocytes Do Not Undergo Hypertrophy When Cultured in the Presence of Serum and Osteogenic Protein-1
Biochem Biophys Res Comm V197 (3) p1253-1259, December 30, 1993
Asahina, I., Sampath, T.K., Nishimura, I., and Hauschka, P.V.
Human Osteogenic Protein-1 Induces Both Chondroblastic and Osteoblastic Differentiation of Osteoprogenitor Cells Derived From Newborn Rat Calvaria
J Cell Biol V123 (4) p921-933, November 1993
Knutsen, R., Wergedal, J.E., Sampath, T.K., Baylink, D.J., and Mohan, S.
Osteogenic Protein-1 Stimulates Proliferation and Differentiation of Human Bone Cells In Vitro
Biochem Biophys Res Comm V194 (3) p1352-1358, August 16, 1993

4.    Dental Applications

McAllister, B.S., Margolin, M.D., Cogan, A.G., Taylor, M., Wollins, J.
Residual lateral wall defects following sinus grafting with recombinant human osteogenic protein-1 or Bio-Oss in the chimpanzee
International Journal of Periodontics & Restorative Dentistry V.18/N.3, p.227-239, 1998
Giannobile, W.V., Ryan, S., Shih, M.S., Su, D.L., Kaplan, P.L., Chan, T.C.
Recombinant human osteogenic protein-1 (OP-1) stimulates periodontal wound healing in class III furcation defects
J Periodontal (United States), 69 (2), p. 129-37, Feb. 1998.
Helder, M.N., Karg, H. Bervoets, T.J.M., Vokicevic, S., Burger, E.H., D’Souza, R.N., Woltgens, J.H.M., Karsenty, G., Bronckers, A.L.J.J.
Bone morphogenetic protein-7 (osteogenic protein-1, OP-1) and tooth development
Journal of Dental Research 77 (4) p. 545-554, 1998
Heikinheimo, K., BegueKirn, C., Ritvos, O., Tuuri, T., Ruch, J.V.
Activin and bone morphogenetic protein (BMP) signalling during tooth development
European Journal of Oral Sciences, V106/1 (Jan), p.167-173, 1998
Lee, M.B.
Bone Morphogenetic Proteins: Background and Implications for Oral Reconstruction
J. Clin. Periodontal, v.24, pp. 355-365, 1997
Toyono, T., Nakashima, M., Kuhara, S., Akamine, A.
Expression of TGF-beta superfamily receptors in dental pulp
Journal of Dental Research, V.76/N9 (Sep), p.1555-1560, 1997
Aberg, T., Wozney, J., Thesleff, I.
Expression patterns of bone morphogenetic proteins (BMPs) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation
Developmental Dynamics (US), 1997, 210/4 (383-396)
Terheyden, H., Jepsen S., Vogeler, S., Tucker, M., Rueger, D.C.
Recombinant human osteogenic protein 1 in the rat mandibular augmentation model: differences in morphology of the newly formed bone are dependent on the type of carrier.
Mund Kiefer GesichtsChir (Germany) V5 p 272-5 September 1997
Ripamonti, U., Reddi, A.H.
Tissue engineering, morphogenesis, and regeneration of the periodontal tissues by bone morphogenetic proteins
Crit Rev Oral Biol Med (US) 8 (2), p154-63, 1997
Toyono, T., Nakashima, M., Kuhara, S., Akamine, A.
Temporal changes in expression of tansforming growth factor-beta superfamily members and their receptors during bovine preodontoblast differentitation in vitro
Archives of Oral Biology, V42, N7, p481-488, July, 1997
Jepsen, S., Albers, H.K., Fleiner, B., Tucker, M., Rueger, D.C.
Recombinant Human Osteogenic Protein-1 Induces Dentin Formation: An Experimental Study in Miniature Swine
Journal of Endodontics, V23 N6, p378-382, June 1997
Peterkova, R., Tureckova, J., Lesot, H., Vonesch, J.L., Peterka, M., Ruch, J.V.
Bone morphogenetic proteins (BMPs) and tooth development
Trends in Glycoscience and Glycotechnology, V9, N47, P253-265, May 1997
Jepsen, S., Albers, H-K., Erbersdobler, S., Tucker, M., and Rueger, D.
Osteogenic Protein-1 Induces Reparative Dentin Formation
Proceedings of the International Conference on Dentin/Pulp Complex 1995 and the International Meeting on Clinical Topics of Dentin/Pulp Complex p321-322, Quintessence Publishing, 1996
Ripamonti ,U., Heliotis, M., Rueger D.C., and Sampath, T.K.
Induction of Cementogenesis by Recombinant human osteogenic protein-1 (hOP-1 BMP-7) in the baboon (Papio ursinus)
Arch Oral Biol V41 (1) p121-126, 1996
Rutherford, B., Spangberg, L., Tucker, M., and Charette, M.
Transdentinal Stimulation of Reparative Dentine Formation by Osteogenic Protein-1 in Monkeys
Archs Oral Biol (England) V40 (7) p681-683, July 1995
Cook, S.D., Salkeld, S.L., and Rueger, D.C.
Evaluation of Recombinant Human Ostoegenic Protein-1 (rhOP-1) Placed with Dental Implants in Fresh Extraction sites
Journal of Oral Implantology V21 (4) p281-289, 1995
Rutherford, B.R., Spangeberg, L., Tucker, M., Rueger, D.C., and Charette, M.
The Time-Course of the Induction of Reparative Dentine Formation in Monkeys by Recombinant Human Osteogenic Protein-1
Archs Oral Biol (England) V39 (10) p833-838, 1994
Rutherford R.B., Wahle, J., Tucker, M., Rueger, D., and Charette, M.
Induction of Reparative Dentine Formation in Monkeys by Recombinant Human Osteogenic Protein-1
Arch Oral Biol (England) V38 (7) p571-576, July 1993
Rutherford, R.B, Sampath, K., Rueger, D.C., Taylor, T.D.
Use of Bovine Osteogenic Protein to Promote Rapid Osseointegration of Endosseous Dental Implants
The International Journal of Oral and Maxillofacial Implants V.7 p. 297-301, 1992

5.     Renal Applications

Vukicevic S, Basic V, Rogic D, Basic N, Shih MS, Shepard A, Jin D, Dattatreyamurty B, Jones W, Dorai H, Ryan S,
Griffiths D, Maliakal J, Jelic M, Pastorcic M, Stavljenic A, Sampath TK
Osteogenic Protein-1 (Bone Morphogenetic Protein-7) Reduces Severity of Injury After Ischemic Acute Renal Failure in Rat
J Clin Invest. 1998 Jul 1;102(1):202-14
Vainio, S., Muller, U.
Inductive Tissue Interactions, Cell Signaling, and the Control of Kidney Organogenesis
Cell, v.90, pp. 975-978, 1997
Piscione, T.D., Tino, D., Yager, T.D., Gupta, I.R., Grinfeld, B., Pei, Y., Attisano, L., Wrana, J.L., Rosenblum, N.D.
BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis
American Journal of Physiol., v273(6/2), p F961-975, 1997
Woolf, A.S., Cale, C.M.
Roles of growth factors in renal development
Current Opnion in Nephrology and Hypertension (United Kingdom), 6/1 p10-14, 1997
Lechner, M.S., Dressler, G.R.
The molecular basis of embryonic kidney development
Mech Dev (IRELAND) 62 (2) p105-20, March, 1997
Basic N.
The role of bone morphogenetic proteins in compensatory renal growth
Lijec, Vjesn (CROATIA) 119 (2) p53-5, Feb, 1997
Vukicevic, S., Kopp, J.B., Luyten, F.P., Sampath, T.K.
Induction of Nephrogenic Mesenchyme by Osteogenic Protein-1 (Bone Morphogenetic Protein-7)
Proc Natl Acad of Sci USA 93 (17) p9021-9026, 1996
Ekblom, P.
Genetics of Kidney Development
Current Opinion in Nephrology and Hypertension (United Kingdom) 5/3 p282-287, 1996
Ishibashi, K., Sasaki, S., Akiba, T., and Marumo, F.
Expression of Bone Morphogenetic Protein 7 mRNA in MDCK Cells
Biochem Biophys Res Commun V193 (1) p235-239, May 28, 1993

6.     Neurology Applications

Kawamata, R., Ren, J., Chan, T.C.K., Charette, M., Finklestein, S.
Intracisternal osteogenic protein-1 enhances functional recovery following focal stroke
NeuroReport, V.9/N.7, p.1441-1445, 1998
Song, Q., Mehler, M.F., Kessler, J.A.
Bone morphogenetic proteins induce apoptosis and growth factor dependence of cultured sympathoadrenal progenitor cells
Developmental Biology (United States), V.196/N.1, p. 119-127, Apr. 1, 1998
Carri, N.G., Bengtsson, H., Charette, M.F., Ebendal, T.
BMPR-II expression and OP-1 effects in developing chicken retinal explants
Neuroport 9 (6), p. 1097-1101, 1998
Guo, X., Rueger, D., Higgins, D.
Osteogenic protein-1 and related bone morphogenetic proteins regulate dendritic growth and the expression of microtubule-associated protein-2 in rat sympathetic neurons
Neuroscience Letters 245 (3), p. 131-134, 1998
Ebendal, T., Bengtsson, H., Soderstrom, S.
Bone morphogenetic proteins and their receptors: Potential functions in the brain
Journal of Neuroscience Research 51 (2), p.139-146, 1998
Graham, A.
The origin of dorsoventral patterning of the vertebrate nervous system
Trends Genet (England), V13(12), p.463-465, Dec 1997
Guo, X., Metzler-Northrup, J., Lein, P., Rueger, D.C., Higgins, D.
Leukemia inhibitory factor and ciliary neurotrophic factor regulate dendritic growth in cultures of rat sympathetic neurons
Developmental Brain Research 104 (1997), 101-110.
Sharp, D.J., Yu, W., Ferhat, L., Kuriyama, R., Rueger, D.C., Baas, P.W.
Identification of a Microtubule-associated Motor Protein Essential for Dendritic Differentiation
The Journal of Cell Biology, V138, N4, p833-843, August 25, 1997
Lochter, A., Schachner, M.
Inhibitors of protein kinases abolish ECM-Mediated promotion of neuronal polarity
Experimental Cell Research, V235, N1, p124-129, August 25, 1997
Dale, J.K., Vesque, C., Lints, T.J., Sampath, T.K., Furley, A., Dodd, J., Placzek, M.
Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm
Cell (US) 90 (2), P257-69, July 25, 1997
Mehler, M.F., Mabie, P.C., Zhang, D.M., Kessler, J.A.
Bone morphogenetic proteins in the nervous system
Trends in Neurosciences, V20, N7, p309-317, July, 1997
Lewen, A., Soderstrom, S., Hillered, L., Ebendal, T.
Expression of Serine/Threonine Kinase Receptors in Traumatic Brain Injury
Neuroreport, V8 N2 p475-479, January 20, 1997
Arkell, R., Beedington, R.S.
BMP-7 Influences Pattern and Growth of the Developing Hindbrain of Mouse Embryos
Development (ENGLAND) V124 (1) p1-12, January 1997
Heyd, B., Aebischer, P.
Neurotrophic Factors and Their Clinical Potential
J M-S (Medecine Sciences) V102 Issue 004 12 (3) p299-302, 1996
Lein, P., Guo, X., Hedges, A.M., Rueger, D.C., Johnson, M. and Higgins, D.
The Effects of Extracellular Matrix and Osteogenic Protein-1 on the Morphological Differentiation of Rat Sympathetic Neurons
Int J Devl Neuroscience, V14 N3 p203-215, 1996
Reissmann, E., Ernsberger, U., Francis-West, P.H., Rueger, D., Brickell, P.M., and Rohrer, H.
Involvement of Bone Morphogenetic Protein-4 and Bone Morphogenetic Protein-7 in the Differentiation of the Adrenergic Phenotype in Developing Sympathetic Neurons
Development V122 p2079-2088, 1996
Varley, J.E., Wehby, R.G., Rueger, D.C., and Maxwell, G.D.
Number of Adrenergic and Islet-1 Immunoreactive Cells is Increased in Avian Trunk Neural Crest Cultures in the Presence of Human Recombinant Osteogenic Protein-1
Developmental Dynamics V203 (4) p434-447, 1995
Lein, P., Johnson, M., Guo, X., Rueger, D.C., and Higgins, D.
Osteogenic Protein-1 Induces Dendritic Growth in Rat Sympathetic Neurons
Neuron V15 p597-605, 1995
Hawley, S.H., Wunnenberg-Stapleton, K., Hashimoto, C., Laurent, M.N., Watabe, T., Blumberg, B.W., and Cho, K.W.
Disruption of BMP Signals in Embryonic Xenopus Ectoderm Leads to Direct Neural Induction
Genes Dev V9 (23) p2923-2935, December 1, 1995
Perides, G., Jensen, F.E., Edgecomb, P., Rueger, D.C., and Charness, M.E.
Neuroprotective Effect of Human Osteogenic OP-1 in a Rat Model of Cerebral Hypoxial/Ischemia
Neuroscience Letters V187 (1) p21-24, February 24, 1995
Perides, G., Safran, R.M., Downing, L.A., and Charness, M.E.
Regulation of Neural Cell Adhesion Molecule and L1 by the Transforming Growth Factor-B Superfamily. Selective Effects of the Bone Morphogenetic Proteins
J Biol Chem V269 (1) p765-770, January 7, 1994
Charness, M.E., Safran, R.M., and Perides, G.
Ethanol Inhibits Neural Cell-cell Adhesion
J Biol Chem, V269 (12) p9304-9309, March 25, 1994
Perides, G., Hu, G., Rueger, D.C., and Charness, M.E.
Osteogenic Protein-1 Regulates L1 and Neural Cell Adhesion Molecule Gene Expression in Neural Cells
J Biol Chem V268 (33) p25197-25205, November 25, 1993
Perides, G., Safran, R.M., Rueger, D.C., and Charness, M.E.
Induction of the Neural Cell Adhesion Molecule and Neuronal Aggregation by Osteogenic Protein-1
Proc Natl Acad Sci V89 (21) p10326-10330, November 1, 1992

7.    Other BMP Applications

Weber, K.L., Bolander, M.E., Rock, M.G., Sarkar, G.
Evidence for the upregulation of osteogenic protein-1 mRNA expression in musculoskeletal neoplasms
Journal of Orthopaedic Research 16 (1), p. 8-14, 1998
÷zkaynack, E., Jin, D., Jelic, M., Vukicevic, S., Oppermann, H.
Osteogenic protein-1 mRNA in the uterine endometrium
Biochemical and Biophysical Research Communications 234 (1), p242-246, 1997
Ramanathan, R., Wilkemeyer, M.F., Mittal, B., Perides, G., and Charness, M.E.
Alcohol Inhibits Cell-Cell Adhesion Mediated by Human L1
Journal of Cell Biology V133 (2) p381-390, April 1996
Martinovic, S,. Latin, V., Suchanek, E., Stavljenic-Rukavina, A., Sampath, T.K., and Vukicevic, S.
Osteogenic Protein-1 is Produced by Human Fetal Trophoblasts In-vivo and Regulates the Synthesis of Chorionic-Gonadotropin and Progesterone by Trophoblasts In-Vitro
European Journal of Clinical Chemistry and Clinical Biochemistry V34 (2) p103-109, February 1996
Solursh, M., Langille, R.M., Wood, J., and Sampath, T.K.
Osteogenic Protein-1 is Required for Mammalian Eye Development
Biochem Biophys Res Commun V218 (2) p438-443, January 17, 1996
Yamada, N., Kato, M., ten Dijke, P., Yamashita, H., Sampath, T.K., Heldin, C-H, Miyazono, K., and Funa, K.
Bone Morphogenetic Protein Type IB Receptor is Progressively Expressed in Malignant Glioma Tumors
British Journal of Cancer V73 (5) p624-629, 1996
Andrews, P.W., Damjanov, I., Berends, J., Kumpf, S., Zappavigna, V., Mavilio, F., and Sampath, T.K.
Inhibition of Proliferation and Induction of Differentiation of Pluripotent Human Embryonal Carcinoma Cells by Osteogenic Protein-1 (or Bone Morphogenic Protein-7)
Laboratory Investigation V71 (2) p243-251, August 1994
Andrews, P.W., Mavilio, F., Zappavigna, V., and Sampath, T.K.
Growth Inhibition and Differentiation of a Human Embryonal Carcinoma (EC) Cell Line by Osteogenic Protein-1 (OP-1)
Advances in the Biosciences (ENGLAND) V91, p151-152, 1994
Lefer, A.M., Tsai, P.S., Ma, X.L., and Sampath, T.K.
Anti-Ischaemic and Endothelial Protective Actions of Recombinant Human Osteogenic Protein (hOP-1)
J Mol Cell Cardiol V24 (6) p585-593, June 1992


8.    Single-Chain Antibodies

George, A.J.T. and Huston, J.S.
Bispecific Antibody Engineering
The Antibodies, V.4, p.99-141, 1997
Keck, P.C., and Huston, J.S.
Symmetry of Fv Architecture is Conductive to Grafting a Second Antibody Binding Site in the Fv Region
Biophysical Journal, p.2002-2011, 1996
Huston, J.S., and Haber, E.
An Overview of the 1996 Keystone Meeting. Exploring and Exploiting Antibody and Ig Superfamily Combining Sites
Immunotechnology, p.253-260, 1996
Huston, J.S., Margolies, M.M., and Haber, E.
Antibody Binding Sites
Advances in Protein Chemistry, p.329-450, 1996
McCartney, J.E., Oppermann, H., Heelan, B.T., Peters, A.M., Houston, L.L., Bookman, M.A., Wolf, E.J., and Weiner, L.M.
Single-Chain Fv Radioimmunotargeting
Quarterly Journal of Nuclear Medicine, p.320-333, 1996
George, A.J.T., Huston, J.S., and Haber, E.
Exploring and Exploiting the Antibody and Ig Superfamily Combining Sites
Nature Biotechnology, p.584, 1996
Tai, M.S., McCartney, J.E., Adams, G.P., Jin, D., Hudziak, R.M., Oppermann, H., Laminet, A.A., Bookman, M.A., Liu, S., Stafford III, W.F., Fand, I., Houston, L.L., Weiner, L.M., and Huston, J.S.
Targeting c-erbB-2 Expressing Tumors Using Single-Chain Fv Monomers and Dimers
Cancer Research, p.5983s-5989s, 1995
Schier, R., Marks, J.D., Wolf, E.J., Apell, G., Wong, C., McCartney, J.E., Bookman, M.A., Huston, J.S., Houston, L.L., Weiner, L.M., and Adams, G.P.
In Vitro and In Vivo Characterization of a Human Anti-c-erbB-2 Single-Chain Fv Isolated from a Filamentous Phage Antibody Library
Immunotechnology, p.73-81, 1995
George, A.J.T., Jamar, F., Tai, M.S., Heelan, B.T., Adams, G.P., McCartney, J.E., Houston, L.L., Weiner, L.M., Oppermann, H., Peters, A.M., and Huston, J.S.
Radiometal Labeling of Recombinant Proteins by a Genetically Engineered, Minimal Chelation Site: Technetium-99m Coordination by Single-Chain Fv Antibody Fusion Proteins Through a C-Terminal Cysteinyl Peptide
Proc. Natl. Acad. Sci., p.8358-8362, 1995
Adams, G.P., McCartney, J.E., Wolf, E.J., Eisenberg, J., Huston, J.S., Bookman, M.A., Moldofsky, P., Stafford III, W.F., Houston, L.L., and Weiner, L.M.
Enhanced Tumor Specificity with Stably Iodinated 741F8-1 (sFv')2, an Anti-c-erbB-2 Single-Chain Fv Dimer
Journal of Nuclear Medicine, p.2276-2281, 1995
Adams, G.P., McCartney, J.E., Wolf, E.J., Oppermann, H., Tai, M.S., Eisenberg, J., Giantonio, B., Schultz, J., Bookman, M.A., Laminet, A., Apell, G., Stafford III, W.F., Liu, S., Huston, J.S., Houston, L.L., and Weiner, L.M.
Preclinical Studies and Optimization of Specific Tumor Delivery for 741F8 anti-c-erbB-2 Single-Chain Fv Species
Intl. Journal of Pharmacognosy, p.75-91, 1995
Huston, J.S.
Reinventing the Trojan Horse of Cancer Therapy
Tumor Targeting, p.125-127, 1995
Adams, G.P., McCartney, J.E., Wolf, E.J., Eisenberg, J., Tai, M.S., Huston, J.S., Stafford III, W.F., Bookman, M.A., Houston, L.L., and Weiner, L.M.
Optimization of In Vivo Tumor Targeting in SCID Mice with Divalent Forms of 741F8 Anti-c-erbB-2 Single-Chain Fv: Effects of Dose Escalation and Repeated i.v. Administration
Cancer Immunology and Immunotherapy, p.299-306, 1995
McCartney, J.E., Tai, M.S., Hudziak, R.M., Adams, G.P., Weiner, L.M., Jin, D., Stafford III, W.F., Liu, S., Bookman, M.A., Laminet, A.A., Fand, I., Houston, L.L., Oppermann, H., and Huston, J.S.
Engineering Disulfide-Linked Single-Chain Fv Dimers [(sFv')2] with Improved Solution and Targeting Properties: Anti-Digoxin 26-10 (sFv')2 and Anti-c-erbB-2 741F8 (sFv')2 made by Protein Folding and Bonded through C-Terminal Cysteinyl Peptides
Protein Engineering, p.301-314, 1995
George, A.J.T., Titus, J.A., Jost, C.R., Kurucz, I., Perez, P., Andrew, S.M., Nicholls, P.J., Huston, J.S., and Segal, D.M.
Redirection of Cellular Cytotoxicity: a Two-Step Approach Using Recombinant Single-Chain Fv Molecules
Cell Biophysics, p.153-165, 1995
Weiner, L.M., Houston, L.L., Huston, J.S., McCartney, J.E., Tai, M.S., Appel, G., Stafford III, W.F., Bookman, M.A., Gallo, J., and Adams, G.P.
Improving the Tumor-Selective Delivery of Single-Chain Fv Molecules
Tumor Targeting, p.51-60, 1995
Huston, J.S., George, A.J.T., Tai, M.S., McCartney, J.E., Jin, D., Segal, D.M., and Oppermann, H.
Single-Chain Fv Design and Production by Preparative Folding
Antibody Engineering, p.185-227, 1995
Huston, J.S., Adams, G.P., McCartney, J.E., Tai, M.S., Oppermann, H., Liu, S., Stafford III, W.F., Bookman, M.A., Fand, I., Apell, G., Laminet, A., Houston, L.L., and Weiner, L.M.
Tumor Targeting in a Tumor Xenograft Model with the (sFv')2 Divalent Form of Aanti-c-erbB-2 Single-Chain Fv
Cell Biophysics, p.249-257, 1994
Dorai, H., McCartney, J.E., Hudziak, R.M., Tai, M.S., Laminet, A.A., Houston, L.L., Huston, J.S., and Oppermann, H.
Mammalian Cell Expression of Single-Chain Fv (sFv) Antibody Proteins and their C-Terminal Fusions with Interleukin-2 and other Effector Domains
Bio/Technology, p.890-897, 1994
George, A.J.T., Titus, J.A., Jost, C.R., Kurucz, I., Perez, P., Andrew, S.M., Nicholls, P.J., Huston, J.S., and Segal, D.M.
Redirection of T Cell-Mediated Cytotoxicity by a Recombinant Single-Chain Fv Molecule
J. Immunology, p.1802-1811, 1994
Nedelman, M.A., Shealy, D.J., Boutin , R., Brunt, E., Seasholtz, J.I., Allen I.E., Weisman, H.F., McCartney, J.E., Warren, F.D., Oppermann, H., Pang, R.H.L., and Berger, H.J.
Rapid Infarct Imaging with a Technetium-99m Antimyosin sFv Fragment: Evaluation in a Canine Model of Acute Myocardial Infarction
J. Nuclear Med., p.234-241, 1993
Huston, J.S., Tai, M.S., McCartney, J., Keck, P., and Oppermann, H.
Antigen Recognition and Targeted Delivery by the Single-Chain Fv
Cell Biophysics, p.189-224, 1993
Huston, J.S., Keck, P., Tai, M.S., Jin, D., McCartney, J., Stafford III, W.F., Mudgett-Hunter, M., Oppermann, H., and Haber, E.
Single-Chain Immunotechnology of Fv Analogues and Fusion Proteins
In Immunotechnology, p.47-60, 1993
Adams, G.P., McCartney, J.E., Tai, M.S., Oppermann, H., Huston, J.S., Stafford III, W.F., Bookman, M.A., Fand, I., Houston, L.L., and Weiner, L.M.
Highly Specific In Vivo Tumor Targeting by Monovalent and Divalent Forms of 741F8 Anti-c-erbB-2 Single-Chain Fv
Cancer Research, p.4026-4034, 1993
Huston, J.S., McCartney, J., Tai, M.S., Mottola-Hartshorn, C., Jin, D., Warren, F., Keck, P., and Oppermann, H.
Medical Applications of Single-Chain Antibodies
International Reviews of Immunology, p.195-217, 1993
McCartney, J.E., Tai, M.S., Oppermann, H., Jin, D., Warren, F.D., Weiner, L.M., Bookman, M.A., Stafford III, W.F., Houston, L.L., and Huston, J.S.
Refolding of Single-Chain Fv with C-Terminal Cysteine (sFv'): Formation of Disulfide-Bonded Homodimers of Anti-c-erbB-2 and Aanti-Digoxin sFv'
Miami Short Reports, p.91, 1993
Huston, J.S., Cohen, C., Maratea, D., Fields, F., Tai, M.S., Cabral-Denison, N., Juffras, R., Rueger, D.C., Ridge, R.J., Oppermann, H., and Baird, L.G.
Multisite Association by Recombinant Proteins can Enhance Binding Selectivity: Preferential Removal of Immune Complexes from Serum by Immobilized Truncated FB Analogues of the B Domain from Staphylococcal Protein A
Biophysical Journal, p.87-91, 1992
McCartney, J., Lederman, L., Drier, E., Cabral-Denison, N., Wu, G.M., Batorsky, R., Huston, J.S., and Oppermann, H.
Biosynthetic Antibody Binding Sites: Development of a Single-Chain Fv Model Based on Anti-Dinitrophenol IgA Myeloma MOPC 315
Journal of Protein Chemistry, p.669-683, 1991
Huston, J.S., Mudgett-Hunter, M., Tai, M.S., McCartney, J., Warren, F., Haber, E., and Oppermann, H.
Protein Engineering of Single-Chain Fv Analogues and Fusion Proteins
Methods in Enzymology, p.46-88, 1991
Andrew, S.M., Perez, P., Nicholls, P.J., George, A.J.T., Huston, J.S., Oppermann, H., and Segal, D.
Production of a Single Chain Bispecific Antibody by Recombinant DNA Technology
Bispecific Antibodies and Targeted Cellular Cytotoxicity, Proceedings of the Second International Conference, p.197-199
Huston, J.S., Tai, M.S., McCartney, J., Warren, F., Mudgett-Hunter, M., Oppermann, H.
Bifunctional Single-Chain Fv Fusion Proteins
Bispecific Antibodies and Targeted Cellular Cytotoxicity, Proceedings of the Second International Conference, p.201-206
Tai, M.S., Mudgett-Hunter, M., Levinson, D., Wu, G.M., Haber, E., Oppermann, H., and Huston, J.S.
A Bifunctional Fusion Protein Containing Fc-Binding Fragment B of Staphylococcal Protein A Amino Terminal to Antidigoxin Single-Chain Fv
Biochemistry, p.8024-8030, 1990
McCartney, J., Lederman, L., Drier, E., Wu, G.M., Cabral-Denison, N., Huston, J.S., and Oppermann, H.
Biosynthetic Antibody Binding Site (BABS) Proteins: Binding Activities of MOPC 315 VH, Fv and Single-Chain Fv
ICSU Short Reports, p.114, 1990
Huston, J.S., Levinson, D., Mudgett-Hunter, M., Tai, M.S., Novotny, J., Margolies, M.N., Ridge, R.J., Bruccoleri, R.E., Haber, E., Crea, R., and Oppermann, H.
Protein Engineering of Antibody Binding Sites: Recovery of Specific Activity in an Anti-Digoxin Single-Chain Fv Analogue Produced in Escherichia Coli
Proc. Natl. Acad. Science, 5879-5883, 1988

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