1. General Review
Articles of BMPs
- Sakou, T.
- Bone
morphogenetic proteins: From basic studies to clinical approaches
- Bone (United States), V.22/N.6 p. 591-603, 1998
-
- Reddi, A.H.
- Role
of Morphogenetic Proteins in Skeletal Tissue Engineering and Regeneration
- Nature Biotechnology, v.16, p.247-252, 1998
-
- Wozney, JM, Rosen, V.
- Bone
morphogenetic protein and bone morphogenetic protein gene family in bone formation and
repair
- Clinical Orthopaedics and Related Research N.346 (Jan), p.26-37, 1998
-
- Vukicevic, S., Latin, V., Chen, P., Batorksy, R., Wozney, J.M.
- The bone morphogenetic protein family: multifunctional cellular regulators in the
embryo and adult
- European Journal of Oral Sciences, V106/1 (Jan), p.160-166, 1998
-
- Ripamonti, U., Duneas, N.
- Tissue
morphogenesis and regeneration by bone morphogenetic proteins
- Plastic and Reconstructive Surgery, V.101/N1 (Jan), p.227-239, 1998
-
- Roelen, B.A.J., Goumans, M.J., VanRooijen, M.A., Mummery, C.L.
- Differential
expression of BMP receptors in early mouse development
- International Journal of Developmental Biology, V41, N4, p541-549, Aug, 1997.
-
- Rosen, V., Cox, K., Hattersley, G.
- Bone Morphogenetic Proteins
- Principles of Bone Biology, Chapter 47, pp. 661-671, (book) 1996
-
- Yamashita, H., Tendijke, P., Heldin, C.H., Miyazono, K.
- Bone
morphogenetic protein receptors
- Bone, V19, N6, p569-574, December, 1996
-
- Rosen, V., Thies, R.S., Lyons, K.
- Signaling
Pathways in Skeletal Formation: A Role for BMP Receptors
- Ann NY Acad Sci V785 p59-69, 1996
-
- Karsenty, G., Luo, G., Hofmann, C., Bradley, A.
- BMP-7
is Required for Nephrogenesis, Eye Development, and Skeletal Patterning
- Ann NY Acad Sci V785 p98-107, 1996
-
- King, J.A., Storm, E.E., Marker, P.C., Dileone, R.J., Kingsley, D.M.
- The
Role of BMPs and GDFs in Development of Region-specific Skeletal Structures
- Ann NY Acad Sci V785 p70-79, 1996
-
- Linkhard, T.A., Subburaman, M. and Baylink D.J.
- Growth
Factors for Bone Growth and Repair: IGF, TGF-B and BMP
- Bone V19, No. 1 Supplement, p1S-12S, July 1996
-
- Hogan, B.L.M.
- Bone
Morphogenetic Proteins: Multifunctional Regulators of Vertebrate Development
- Genes & Development V10, p1580-1594, 1996
-
- Massague, J.
- TGF-B
Signaling: Receptors, Transducers, and Mad Proteins
- Cell V85 p947-950, June 28, 1996
-
- Cook, S.D., and Rueger, D.C.
- Osteogenic
Protein-1: Biology and Applications
- Clin Orthop (324) p29-38, March 1996
-
- Rudkin, G.H., and Miller, T.A.
- Growth-Factors
in Surgery
- Plastic and Reconstructive Surgery V97 (2) p469-476, February 1996
-
- Ripamonti, U., Reddi, A.H.
- Bone Morphogenetic Proteins: Applications in Plastic and Reconstructive Surgery
- Advances in Plastic & Reconstructive Surgery, v.11, pp. 47-73, 1995
-
- Vukicevic, S., Stavljenic, A., and Pecina, M.
- Discovery
and Clinical Applications of Bone Morphogenetic Proteins
- European Journal of Clinical Chemistry and Clinical Biochemistry V33 (10) p661-671,
October 1995
-
- Kirkerhead, C.A.
- Recombinant
Bone Morphogenetic Proteins - Novel Substances for Enhancing Bone Healing
- Veterinary Surgery V24 (5) p408-419 September-October 1995
-
- Ripamonti, U., and Vukicevic, S.
- Bone Morphogenetic Proteins - from Developmental Biology to Molecular Therapeutics
- South African Journal of Science V91 (6) p277-280, June 1995
-
- Einhorn, T.A.
- Current
Concepts Review Enhancement of Fracture-healing
- The Journal of Bone and Joint surgery, V77-A (6), p.940-956, June 1995
-
- Wozney, J.M.
- The
Potential Role of Bone Morphogenetic Proteins in Periodontal Reconstruction
- J of Periodontology V66 (6) p506-510, June 1995
-
- Einhorn, T.A.
- Enhancement
of Fracture-healing
- J of Bone and Joint Surgery (American) V077A (6) p940-956, June 1995
-
- Reddi, A.H.
- Bone
Morphogenetic Proteins, Bone Marrow Stromal Cells, and Mesenchymal Stem Cells
- Clinical Orthopaedics and Related Research, N313, p115-119, 1995
-
- Sampath, T.K., and Rueger, D.C.
- Structure, Function, and Orthopedic Applications of Osteogenic Protein-1 (OP-1)
- Complications in Orthopedics p101-107, Winter 1994
-
- Alper, J.
- Biomedicine
- Boning Up - Newly Isolated Proteins Heal Bad Breaks
- Science V263 (5145) p324-325, January 21, 1994
-
- Ripamonti, U., and Reddi, A.H.
- Periodontal
Regeneration - Potential Role of Bone Morphogenetic
- J of Periodontal Research V29 (4) p225-235, July 1994
-
- Wolfe, M.W., and Cook, S.D.
- Use
of Osteoinductive Implants in the Treatment of Bone Defects
- Med Prog Technol (US) V20 (3-4) p155-168, 1994
-
- Kingsley, D.M.
- What
do BMPs do in Mammals - Clues from the Mouse Short Ear Mutation
- Trends in Genetics V10 (1) p 16-21, 1994
-
- Reddi, A.H., and Cunningham, N.S.
- Initiation
and Promotion of Bone Differentiation by Bone Morphogenetic Proteins
- J Bone Miner Res (US) V8 (S2) pS499-S502, December 1993
-
- Kenley, R.A., Yim, K., Abrams, J., Ron, E., Turek, T., Marden, L.J., and Hollinger, J.O.
- Biotechnology
and Bone-graft Substitutes
- Pharmaceutical Research V10 (10) p1393-1401, October 1993
-
- Elima, K.
- Osteoinductive
Proteins
- Annals of Medicine V25 (4) p395-402, August 1993
-
- Baylink, D.J., Finkelman, R.D., and Mohan S.
- Growth-Factors
to Stimulate Bone-formation
- J of Bone and Miner Res V8 (S2) pS565-S572, December 1993
-
- Wang, E.A.
- Bone
Morphogenetic Proteins (BMPs) - Therapeutic Potential in Healing Bony Defects
- Trends in Biotechnology V11 (9) p379-383, September 1993
-
- Wozney, J.M.
- The
Bone Morphogenetic Protein Family and Osteogenesis
- Mol Reprod Dev V32 (2) p160-167, June 1992
-
- Lyons, K.M., Jones, C.M., and Hogan, B.L.
- The
DVR Gene Family in Embryonic Development
- Trends Genet (England) V7 (11-12) p408-412, November - December 1991
-
- Wozney, J.M., Rosen, V., Byrne, M., Celeste, A.J., Moutsatsos, I., and Wang, E.A.
- Growth
Factors Influencing Bone Development
- J Cell Sci Suppl (England) V13 p149-156, 1990
-
- Wozney, J.M.
- Bone
Morphogenetic Proteins
Prog Growth Factor Res (England) V1 (4) p267-280, 1989
-
2.
Molecular
Biology and Biochemistry of BMPs
- Amthor, H., Christ, B., Weil, M., Patel, K.
- The
importance of timing differentiation during limb muscle development
- Current Biology V.8/N.11 p. 642-652, 1998
-
- Onishi, T., Ishidou, Y., Nagamine, T., Yone, K., Imamura, T., Kato, M., Sampath, T.K.,
Ten Dijke, P., Sakou, T.
- Distinct
and overlapping patterns of localization of bone morphogenetic protein (BMP) family
members and a BMP type II receptor during fracture healing in rats
- Bone (United States) V.22/N.6, p. 605-612, 1998
-
- Ericson, J., Norlin, S., Jessell, T.M., Edlund, T.
- Integrated
FGF and BMP signaling controls the progression of progenitor cell differentiation and the
emergence of pattern in the embryonic anterior pituitary
- Development (United Kingdom), V.125/N.6, p. 1005-1015, 1998
-
- Takase, M., Imamura, T., Sampath, T.K., Takeda, K., Ichijo, H., Miyazono, K., Kawabata,
M.
- Induction
of Smad6 mRNA by bone morphogenetic proteins
- Biochemical and BioPhysical Research Communications, v.244(1), p.26-29, 1998
-
- Nakamura, T., Aikawa, T., Iwamoto-Enomoto, M., Iwamoto, M., Higuchi, Y., Maurizio, P.,
Kinto, N., Yamaguchi, A., Noji, S., Kurisu, K., Matsuya, T.
- Induction
of Osteogenic Differentiation by Hedgehog Proteins
- Biochemical & Biophysical Research Communications, v.237, pp. 465-469, 1997
-
- Suzuki, A., Kaneko, E., Maeda, J., Ueno, N.
- Mesoderm
Induction by BMP-4 and -7 Heterodimers
- Biochemical & Biophysical Research Communications, v. 232, pp. 153-156, 1997
-
- Wang, S., Krinks, M., Kleinwaks, L., Moos, M.
- A
novel Xenopus homolog of bone morphogenetic protein-7 (BMP-7)
- Genes Funct. V1(4), p.259-271, 1997
-
- Harada, S.I., Sampath, T.K., Augin, J.E., Rodan, G.A.
- Osteogenic
protein-1 up-regulation of the collagen X promoter activity is mediated by a MEF-2 like
sequence and requires an adjacent AP-1 sequence
- Molecular Endocrinology 11 (12) p1832-1845. 1997
-
- Piek, E., Franzen, P. Heldin, C-H, Ten Dijke, P.
- Characterization
of a 60-kDa cell surface-associated transforming growth factor-beta binding protein that
can interfere with transforming growth factor-beta receptor binding
- Journal of Cellular Physiology 173 (3). p447-459. 1997
-
- Namiki, M., Akiyama, S., Katagiri, T., Suzuki, A., Ueno, N., Yamaji, N., Rosen, V.,
Wozney, J.M., Suda, T.
- A
kinase domain-truncated type I receptor blocks bone morphogenetic protein-2 induced signal
transduction in C2C12 myoblasts
- Journal of Biological Chemistry, V272, N35, p22046-22052, Aug.1997
-
- Hayashi, K., Ishidou, Y., Yonemori, K., Nagamine, T., Origuchi, N., Maeda, S., Imamura,
T., Kato, M., Yoshida, H., Sampath, T.K., ten Dijke, P., Sakou, T.
- Expression
and localization of bone morphogenetic proteins (BMPs) and BMP receptors in ossification
of the ligamentum flavum
- Bone (US) 21 (1), p23-30, July 1997
-
- Ethier, J.F., Lussier, J.G., Silversides, D.W.
- Bovine
activin receptor type IIB messenger ribonucleic acid displays alternative splicing
involving a sequence homologous to Src-hmology 3 domain binding sites
- Endocrinology, V138, N6, p2425-2434, June, 1997
-
- Beppu, H., Minowa, O., Miyazono, K., Kawabata, M.
- cDNA
cloning and genomic organization of the mouse BMP type II receptor
- Biochemical and Biophysical Research Communications, V235, N3 , p499-504, June 27, 1997
-
- Koyama, H.
- Analysis
of genes implicated in osteogenic signaling by osteogenic protein-1 (OP-1) using
differential display method
- Kokubyo Gakkai Zasshi (Japan) 64 (2) p205-22, , June, 1997
-
- Suzuki, A., Kaneko, E., Ueno, N., Hemmati-Brivanlou, A.
- Regulation
of epidermal induction by BMP2 and BMP7 signaling
- Dev Biol (US) 189 (1) P112-22, Sept. 1997
-
Yonemori, K., Imamura, T., Ishidou, Y., Okano, T., Matsunaga, S., Yoshida, H., Kato,
M., Sampath, T.K., Miyazono, K., ten Dijke, P., Sakou, T.
- Bone
Morphogenetic Protein Receptors and Activin Receptors are Highly Expressed in Ossified
Ligament Tissues of Patients with Ossification of the Posterior Longitudinal Ligament
- American Journal of Pathology V150 N4 p1335-1347, April 1997
-
- Buscher, D., Bosse, B., Heymer, J., Ruther, U.
- Evidence
for genetic control of Sonic hedgehog by Gil3 in mouse limb development
- Mech Dev (Ireland) 62 (2) p175-82, March, 1997
-
- Dudley, A.T., Robertson, E.J.
- Overlapping
Expression Domains of Bone Morphogenetic Protein Family Members Potentially Account for
Limited Tissue Defects in BMP-7 Deficient Embryos
- Developmental Dynamics V208 N3 p349-362, March 1997
-
- Macias, D., Ganan, Y., Sampath, T.K., Piedra, M.E., Ros M.A., Hurie, J.M.
- Role
of BMP-2 and OP-1 (BMP-7) in Programmed Cell Death and Skeletogenesis during Chick Limb
Development
- Development V124 N6 p1109-1117, March 1997
-
- Feuerbach, D., Loetscher, E., Buerki, K., Sampath, T.K., Feyen, J.H.M.
- Establishment
and Characterization of Conditionally Immortalized Stromal Cell Lines from a
Temperature-Sensitive T-Ag Transgenic Mouse
- Journal of Bone and Mineral Research V12(2) p179-190, 1997
-
- Jena, N., Martin-Seisdedos, C., McCue, P., Croce, C.M.
- BMP-7
Null Mutation in Mice: Developmental Defects in Skeleton, Kidney, and Eye
- Exp Cell Res (United States) V230 (1) p28-37, January 10, 1997
-
- Israel, D.I., Nove, J., Kerns, K.M., Kaufman, R.J., Rosin, V., Cox, K.A., Wozney, J.M.
- Heterodimeric
Bone Morphogenetic Proteins Show Enhanced Activity In Vitro and In Vivo
- Growth Factors (Switzerland) V13 (3-4) p291-300, 1996
-
- Hofmann, C., Luo, G.B., Balling, R., Karsenty, G.
- Analysis
of Limb Patterning in BMP-7-Deficient Mice
- Dev Genetics V19 N1 p43-50, 1996
-
- Harada, S., Sampath, T.K., Rodan, G.A.
- Identification
of an AP-1 like Response Region for Osteogenic Protein-1 in Type X Collagen Promoter
- Annals of the NY Acad Sci V785 p259-260, 1996
-
- Griffith, D.L., Keck, P.C., Sampath, T.K., Rueger, D.C., and Carlson, W.D.
- Three-dimensional
Structure of Recombinant Human Osteogenic Protein 1: Structural Paradigm for the
Transforming Growth Factor Beta Superfamily
- Proc Natl Acad Sci US V93 (2) p878-883, January 23, 1996
-
- Wall, N.A., and Hogan, B.L.M.
- Expression
of Bone Morphogenetic Protein-4 (BMP-4), Bone Morphogenetic Protein-7 (BMP-7), Fibroblast
Growth Factor-8 (FGF-8) and Sonic Hedgehog (SHH) During Branchial Arch Development in the
Chick
- Mechanisms of Development V53 (3) p383-392, 1995
-
- Ishidou, Y., Kitajima, I., Obama, H., Maruyama, I., Murata, F., Imamura, T., Yamada, N.,
ten Dijke, P., Miyazono, K., and Sakou, T.
- Enhanced
Expression of Type I Receptors for Bone Morphogenetic Proteins During Bone Formation
- Journal of Bone and Mineral Research V10 (11) p1651-1659, November 1995
-
- Luo, G., Hofmann, C., Bronckers, A.L.J., Sohocki, M., Bradley, A., and Karsenty, G.
- BMP-7
is an Inducer of Nephrogenesis, and is also Required for Eye Development and Skeletal
Patterning
- Genes & Development V9 (22) p2808-2820, November 15, 1995
-
- Dudley, A.T., Lyons, K.M., Robertson, E.J.
- A
Requirement for Bone Morphogenetic Protein-7 During Development of the Mammalian Kidney
and Eye
- Genes & Development V9 (22) p2795-2807, November 15, 1995
- Kitten, A.M., Lee, J.C., and Olson, M.S.
- Osteogenic
Protein-1 Enhances Phenotypic Expression in ROS 17/2.8 Cells
- Am J Physiol V269 (5 Pt 1) pE918-E926, November 1995
- Rosenzweig, B.L., Imamura, T., Okadome, T., Cox, G.N., Yamashita, H., ten Dijke, P.,
Heldin, C.H., and Miyazono, K.
- Cloning
and Characterization of a Human Type II Receptor for Bone Morphogenetic Proteins
- Proc Natl Acad Sci U S A (US) V92 (17) p7632-7636, August 15, 1995
-
- Marker, PC., King, J.A., Copeland, N.G., Jenkins, N.A., and Kingsley, D.M.
- Chromosomal
Localization, Embryonic Expression, and Imprinting Tests for BMP-7 on Distal Mouse
Chromosome 2
- Genomics V28 (3) p576-580, August 10, 1995
-
- Yamashita, H., ten Dijke, P., Huylebroeck, D., Sampath, T.K., Andries, M., Smith, J.C.,
Heldin, C.H., and Miyazono, K.
- Osteogenic
Protein-1 Binds to Activin Type II Receptors and Induces Certain Activin-like Effects
- J Cell Bio (US) V130 (1) p217-226, July 1995
-
- Liu, F., Ventura, F., Doody, J., and Massague, J.
- Human
Type II Receptor for Bone Morphogenic Proteins (BMPs) Extension of the Two-kinase Receptor
Model to the BMPs
- Mol Cell Biol V15(7) p3479-3486, July 1995
-
- Dewulf, N., Verschueren, K., Lonnoy, O., Moren, A., Grimsby, S., Vande Spiegle, K.,
Miyazono, K., Huylebroeck, D., ten Dijke, P.
- Distinct
Spatial and Temporal Expression Patterns of Two Type I Receptors for Bone Morphogenetic
Proteins During Mouse Embryogenesis
- Endocrinology (US) V136 (6) p2652-2663, June 1995
-
- Lyons, K.M., Hogan, B.L., and Robertson, E.J.
- Colocalization
of BMP 7 and BMP 2 RNAs Suggests that these Factors Cooperatively Mediate Tissue
Interactions During Murine Development
- Mech Dev (Ireland) V50 (1) p71-83, March 1995
-
- Helder, M.N., Ozkaynak, E., Sampath, K.T., Luyten, F.P., Latin, V., Oppermann, H., and
Vukicevic, S.
- Expression
Pattern of Osteogenic Protein-1 (Bone Morphogenetic Protein-7) in Human and Mouse
Development
- Journal of Histochemistry and Cytochemistry V45 (10) p1035-1044, 1995
-
- Houston, B., Thorp, B.H., and Burt D.W.
- Molecular
Cloning and Expression of Bone Morphogenetic Protein-7 in the Chick Epiphyseal Growth
Plate
- Journal of Molecular Endocrinology V13 (3) p289-301, December 1994
-
- Griffith, D.L., Oppermann, H., Rueger, D.C., Sampath, T.K., Tucker, R.F., and Carlson,
W.D.
- Crystallization
and Preliminary Crystallographic Data of Recombinant Human Osteogenic Protein-1
- J Mol Biol (ENGLAND) V244 (5) p657-658, December 16, 1994
- Postlethwaite, A.E., Raghow ,R., Stricklin, G., Ballou, L., and Sampath, T.K.
- Osteogenic
Protein-1, a Bone Morphogenic Protein Member of the TGF-beta Superfamily, Shares
Chemotactic But Not Fibrogenic Properties with TGF-beta
- J Cell Physiol (US) V161 (3) p562-570, December 1994
- ten Dijke, P., Yamashita, H., Sampath, T.K., Reddi, A.H., Estevez, M., Riddle, D.L.,
Ichijo, H., Heldin, C.H., and Miyazono, K.
- Identification
of Type I Receptors for Osteogenic Protein-1 and Bone Morphogenetic Protein-4
- J Biol Chem V269 (25) p16985-16988, June 1994
-
- Jones, W.K., Richmond, E.A., White, K., Sasak, H., Kusmik, W., Smart, J., Oppermann, H.,
Rueger, D.C., and Tucker, R.F.
- Osteogenic
Protein-1 (OP-1) Expression and Processing in Chinese Hamster Ovary Cells: Isolation of a
Soluble Complex Containing the Mature and Pro-domains of OP-1
- Growth Factors (Switzerland) V11 (3) p215-225, 1994
- Maliakal ,J.C., Asahina, I., Hauschka, P.V., and Sampath, T.K.
- Osteogenic
Protein-1 (BMP-7) Inhibits Cell Proliferation and Stimulates the Expression of Markers
Characteristic of Osteoblast Phenotype in Rat Osteosarcoma
- Growth Factors (SWITZERLAND) V11 (3) p227-34, 1994
- Vukicevic, S., Latin, V., Chen, P., Batorksy, R., Reddi, A.H., and Sampath, T.K.
- Localization
of Osteogenic Protein-1 (Bone Morphogenetic Protein-7) During Human Embryonic Development
- High Affinity Binding to Basement Membranes
- Biochemical and Biophysical Research Communications V198 (2) p693-700, January 28, 1994
-
- Sodek, J., Li, I.W.S., Li, H., Bellows, C.G., McCulloch, C.A.G., Tenebaum, H.C., Ellen,
R.P.
- The Role of TGF-beta and BMP-7 in Regenerating Bone and Soft Tissues
- Mater Sci Eng V2 (1-2) p19-26, 1994
-
- Suzuki, A., Nishimatsu, S., Murakami, K., and Ueno, N.
- Differential
Expression of Xenopus BMPs in Early Embryos and Tissues
- Zoolog Sci (JAPAN), V10 (1) p175-178, February 1993
-
- Sampath, T.K., Rashka, K.E., Doctor, J.S., Tucker, R.F., and Hoffman, F.M.
- Drosophilia
Transforming Growth Factor B Superfamily Proteins Induce Endochondral Bone Formation in
Mammals
- Proc Natl Acad Sci (UNITED STATES) V90 p6004-6008, July 1993
-
- Nishimatsu, S., Suzuki, A., Shoda, A., Murakami, K., and Ueno, N.
- Genes
for Bone Morphogenetic Proteins are Differentially Transcribed in Early Amphibian Embryos
- Biochem Biophys Res Commun V186 (3) p1487-1495, 1992
-
- Hahn, G.V., Cohen, R.B., Wozney, J.M., Levitz, C.L., Shore, E.M., Zasloff, A., Kaplan,
S.
- A
Bone Morphogenetic Protein Subfamily: Chromosome Localization of Human Genes for BMP-5,
BMP-6, and BMP-7
- Genomics V14 (3) p759-762, 1992
-
- Özkaynack, E., Schnegelsberg, P.N.., Jin, D.F., Clifford, G.M., Warren, F.D., Drier,
E.A., and Oppermann, H.
- Osteogenic
Protein-2 a New Member of the Transforming Growth Factor-Beta Superfamily Expressed Early
in Embryogenesis
- J Biol Chem V267 (35) p220-227, December 15, 1992
-
- Sampath, T.K., Maliakal, J.C., Hauschka, P.V., Jones, W.K., Sasak, H., Tucker R.F.,
White, K.H., Coughlin, J.E., Tucker, M.M., Pang, R., Corbett, C., Ozkaynak, E., Oppermann,
H., Rueger, D.C.
- Recombinant
Human Osteogenic Protein-1 (hOP-1) Induces New Bone Formation In Vivo with a
Specific Activity Comparable with Natural Bovine Osteogenic Protein and Stimulates
Osteoblast Proliferation and Differentiation In Vitro
- J Biol Chem V267 (28) p20352-20362, 1992
-
- Özkaynack, E., Schnegelsberg, P.N., and Oppermann ,H.
- Murine
Osteogenic Protein (OP-1): High Levels of mRNA in Kidney
- Biochem Biophys Res Commun V179 (1) p116-123, August 30, 1991
-
Celeste, A.J., Ainnazzi, J.A., Taylor, R.C., Hewick, R.M., Rosen, V., Wang, E.A.,
and Wozney, J.M.
- Identification
of Transforming Growth Factor Beta Family Members Present in Bone-inductive Protein
Purified from Bovine Bone
- Proc Natl Acad Sci USA (US) , V87 (24) p9843-9847, December 1990
-
- Sampath, T.K., Coughlin, J.E., Whetstone, R.M., Banach, D., Corbett, C., Ridge R.J.,
Ozkaynak, E., Oppermann, H., Rueger, D.C.
- Bovine
Osteogenic Protein is Composed of Dimers Of OP-1 And BMP-2A, Two Members of The
Transforming Growth Factor-beta Superfamily
- J Biol Chem V265 (22) p13198-13205, August 5, 1990
-
- Özkaynack, E., Rueger, D.C., Drier, E.A., Corbett, C., Ridge, R.J., Sampath, T.K., and
Oppermann, H.
- OP-1
cDNA Encodes an Osteogenic Protein in the TGF-beta Family
- EMBO J (England) V9 (7) p2085-2093, July 1990
-
- Sampath, T.K., and Reddi, A.H.
- Homology
of Bone-Inductive Proteins from Human, Monkey, Bovine, and Rat Extracellular Matrix
- Proc Natl Acad Sci V80, p6591-6595, November 1983
-
- Sampath, T.K., Reddi, R.H.
- Disassociative
Extraction and Reconstitution of Extracellular Matrix Components Involved in Local Bone
Differentiation
- Proc Natl Acad Sci US V78 (12) p7599-7603, December 1981
-
3.
Orthopaedic
Reconstruction
- Grimsrud, C.D., Rosier, R.N., Puzas, J.E., Reynolds, P.R., Reynolds, S.D., Hicks, D.G.,
O’Keefe, R.J.
- Bone
morphogenetic protein-7 in growth-plate chondrocytes: Regulation by retinoic acid is
dependent on the stage of chondrocyte mutation
- Journal of Orthopaedic Research (United States) V.16/N.2, p.247-255, 1998
- Terkeltaub, R.A., Johnson, K., Rohnow, D., Goomer, R., Burton, D., Deftos, L.J.
- Bone
morphogenetic proteins and bFGF exert opposing regulatory effects on PTHrP expression and
inorganic pyrophosphate elaboration in immortalized murine endochondral hypertrophic
chondrocytes (MCT cells)
- Journal of Bone and Mineral Research (United States), V.13/N.6, p. 931-941, 1998
- Zohar, R., McCulloch, CAG, Sampath K., Sodek, J.
- Flow
cytometric analysis of recombinant human osteogenic protein-1 (BMP-7) responsive
subpopulations from fetal rat calvaria based on intracellular osteopontin content
- Matrix Biology (Germany), V16/6, p.295-306, 1998
- Yeh, L.C.C., Adamo, M.L., Duan, C., Lee, J.C.
- Osteogenic
protein-1 regulates insulin-like growth factor-I (IGF-I), IGF-II, and IGF-binding
protein-5 (IGFBP-5) gene expression in fetal rat calvaria cells by different mechansims
- Journal of Cellular Physiology, V.175/N.1, p. 78-88, 1998
- Erlacher, L., McCartney, J., Piek, E., Dijke, P.T., Yanagishita, M., Oppermann, H.,
Luyten, F.P.
- Cartilage-derived
morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis
- Journal of Bone and Mineral Research (United States), 13/3, p. 383-392, 1998
- Klein-Nulend, J., Louwerse, R.T., Heyligers, I.C., Wuisman, P.I.J.M., Semeins, C.M.,
Goei, S.W., Burger, E.H.
- Osteogenic
protein (OP-1, BMP-7) stimulates cartilage differentiation of human and goat perichondrium
tissue in vitro
- Journal of Biomedical Materials Research 40 (4), p. 614-620, 1998
- Erlacher, L., Ng, CK, Ullrich, R., Krieger, S., Luyten, FP
- Presence
of cartilage-derived morphogenetic proteins in articular cartilage and enhancement of
matrix replacement in vitro
- Arthritis and Rheumatism, V.41/N2 (Feb), p.263-273, 1998
- Grgic, M., Jelic, M., Basic, V., Basic, N., Pecina, M., Vukicevic, S.
- Regeneration
of articular cartilage defects in rabbits by osteogenic protein-1 (bone morphogenetic
protein-7)
- Acta Medica Croatica, V51 (1), p23-27, 1997
Haaijman, A., D’Souza, RN, Bronckers, AL, Goei, SW, Burger EH
OP-1
(BMP-7) affects mRNA expression of type I, II, X collagen, and matrix Gla protein in
ossifying long bones in vitro
J. Bone Miner Res (U.S.), V12(11), p.1815-23, 1997
- Huch, K., Wilbrink, B., Flechtenmacher, J., Koepp, H.E., Aydelotte, M.B., Sampath, T.K.,
Kuettner, K.E., Mollenhauer, J., Thonar, E.J, Thomar, M.A.
- Effects
of recombinant human osteogenic protein 1 on the production of proteoglycan, prostaglandin
E2, and interleukin-1 receptor and antagonist by human articular chondrocytes
cultured in the presence of interleukin-1
- Arthritis Rheum (UNITED STATES), 1997, 40 (12) p2157-61
- Wu, L.N.Y., Ishikawa, Y., Genge, B.R., Sampath, T.K., Wuthier, R.E.
- Effect
of osteogenic protein-1 on the development and mineralization primary cultures of avian
growth plate chondrocytes: Modulation by retinoic acid
- Journal of Cellular Biochemistry 67 (4). 1997. 498-513
- Kitten, A., Harvey, S., Criscimagna, N., Asher, M., Lee, J.C., Olson, M.S.
- Osteogenic
protein-1 downregulates endothelin A receptors in primary rat osteoblasts
- Am. J. Physiol, V272, N6, pE967-E975, 1997
- Yeh, L.C.C., Adamo, M.L., Olson, M.S., Lee, J.C.
- Osteogenic
protein-1 and insulin-like growth factor I synergistically stimulate rat osteoblastic cell
differentiation and proliferation
- Endocrinology, V138, N10, p4181-4190, October 1997
- Hayden, J.M., Strong, d.D., Baylink, D.J., Powell, D.R., Sampath, T.K., Mohan, S.
- Osteogenic
Protein-1 stimulates production of insulin-like growth factor binding protein-3 nuclear
transcripts in human osteosarcoma cells
- Endocrinology, V138, N10, p4240-4247, October, 1997
- Srinivasan, N., Baylink, D.J., Sampath, K., Mohan, S.
- Effects
of inhibitors of signal transduction pathways on transforming growth factor beta 1 and
osteogenic protein-1 induced insulinlike growth factor binding protein-3 expression in
human bone cells
- Journal of Cellular Physiology, V173, N1, p28-35, Oct, 1997
- Ripamonti, U., Duneas, N., VandenHeever, B., Bosch, C., Crooks, J.
- Recombinant
transforming growth factor-beta 1 induces endochondral bone in the baboon and synergizes
with recombinant osteogenic protein-1 (bone morphogenetic protein-7) to initiate rapid
bone formation
- Journal of Bone and Mineral Research, V12 (10), p1584-1595, October, 1997
- Lietman, S.A., Yanagishita, M., Sampath, T.K., Reddi, A.H.
- Stimulation
of proteoglycan synthesis in explants of porcine articular cartilage by recombinant
osteogenic protein-1 (bone morphogenetic protein-7)
- J Bone Joint Surg Am (UNITED STATES) 79 (8) p1132-7, Aug, 1997
- Honda, Y., Knutsen, R., Strong, D.D., Sampath, T.K., Baylink, D.J., Mohan, S.
- Osteogenic
Protein-1 Stimulates mRNA Levels of BMP-6 and Decreases mRNA Levels of BMP-2 and -4 in
Human Osteosarcoma Cells
- Calcified Tissue International V60 N3 p297-301, March 1997
- Renier, M.L., Kohn, D.H.
- Development
and Characterization of a Biodegradable Polyphosphate
- Journal of Biomedical Materials Reearch, V34, N1, P95-104, Jan. 1997
- Ripamonti, U., Van Den Heever, B., Sampath, T.K., Tucker, M.M., Rueger, D.C., Reddi,
A.H.
- Complete
Regeneration of Bone in the Baboon by Recombinant Human Osteogenic Protein-1 (hOP-1, Bone
Morphogenetic Protein-7)
- Growth Factors V13 p273-289, 1996
- Cheifetz, S., Li, I..W.S., McCulloch, C.A.G., Sampath, K., Sodek, J.
- Influence
of Osteogenic Protein-1 (OP-1, BMP-7) and Transforming Growth Factor- 1 on Bone Formation In
Vitro
- Connect Tissue Res V35 (1-4) p71-78, 1996
- Grgic, M.
- The
Effect of Osteogenic Protein-1 (Bone Morphogenetic Protein-7) on Growth in Long Bones in
Rats
- Lijec Vjesn (CROATIA)V118(9) p191-4, September 1996
-
- Yeh L-C C., Adamo, M.L., Kitten, A.M., Olson, M.S., and Lee, J.C.
- Osteogenic
Protein-1-Mediated Insulin-like Growth Factor Gene Expression in Primary Cultures of Rat
Osteoblastic Cells
- Endocrinology (US) V137 (5) p1921-1931, May 1996
- Mayer, H., Scutt, A.M., and Ankenbauer, T.
- Subtle
Differences in the Mitogenic Effects of Recombinant Human Bone Morphogenetic Protein-2 to
Protein-7 on DNA-Synthesis on Primary Bone-Forming Cells and Identification of BMP-2/4
Receptor
- Calcified Tissue International V58 (4) p249-255, April 1996
- Dee, K.C., Rueger, D.C., Andersen, T.T., and Bizios, R.
- Conditions
which Promote Mineralization at the Bone-implant Interface - a Model In-vitro Study
- Biomaterials V17 (2) p209-215, January 1996
- Asahina, I., Sampath, T.K., and Hauschka P.V.
- Human
Osteogenic Protein-1 Induces Chondroblastic, Osteoblastic, and/or Adipocytic
Differentiation of Clonal Murine Target Cells
- Exp Cell Res V222 (1) p38-47, January 10, 1996
- Wall, N.A. and Hogan, B.L.
- Expression
of Bone Morphogenetic Protein-4 (BMP-4), Bone Morphogenetic Protein-7 (BMP-7), Fibroblast
Growth Factor-8 (FGF-8) and Sonic Hedghog (SHH) During Branchial Arch Development in the
Chick
- Mech Dev (IRELAND), V53 (3), p383-92, November 1995
- Mohan, S., Libanati, C., Dony, C., Lang, K., Srinivasan, N., and Baylink, D.J.
- Development,
Validation, and Application of Radioimmunoassay for Insulin-like Growth Factor Binding
Protein-5 in Human Serum and Other Biological Fluids
- J Clin Endocrinol Metab United States V80 (9) p2638-2645, September 1995
- Kanzaki ,S., Baxter, R.C., Knutsen, R., Baylink ,D.J., and Mohan, S.
- Evidence
that Human Bone Cells in Culture Secrete Insulin-like Growth Factor (IGF)-II and IGF
Binding Protein-3 but not Acid-labile Subunit Both Under Basal and Regulated Conditions
- J Bone Mineral Research (US), V10 (6) p854-858, June 1995
- Cook, S.D., Wolfe, M.W., Salkeld, S.L., and Rueger, D.C.
- Effect
of Recombinant Human Osteogenic Protein-1 on Healing of Segmental Defects in Non-human
Primates
- J Bone Joint Surg Am (US) V77 (5) p734-750, May 1995
- Sodek, J., Chen, J., Nagata, T., Kasugai, S., Todescan, R. Jr., Li, I.W., and Kim, R.H.
- Regulation
of Osteopontin Expression in Osteoblasts
- Ann NY Acad Sci V760 p223-241, April 21, 1995
- Hentunen, T.A., Lakkakorpi, P.T., Tuukkanen, J., Lehenkari, P.P., Sampath, T.K., and
Vaananen, H.K.
- Effects
of Recombinant Human Osteogenic Protein-1 on the Differentiation of Osteoclast-like Cells
and Bone Resorption
- Biochem Biophys Res Commun (US) V209 (2) p433-443, April 17, 1995
- Knutsen, R., Honda, Y., Strong, D.D., Sampath, T.K., Baylink, D.J., and Mohan, S.
- Regulation
of Insulin-like Growth Factor System Components by Osteogenic Protein-1 in Human Bone
Cells
- Endocrinology (US) V136 (3) p857-865, March 1995
- Chen, P., Vukicevic, S., Sampath, T.K., and Luyten , F.P.
- Osteogenic
Protein-1 Promotes Growth and Maturation of Chick Sternal Chondrocytes in Serum-free
Cultures
- J Cell Sci (ENGLAND) V108 (Pt 1) p105-114, January 1995
- Aono, A., Hazama, M., Notoya, K., Taketomi, S., Yamasaki, H., Tsukuda, R., Sasaki, S.,
and Fujisawa, Y.
- Potent
Ectopic Bone-inducing Activity of Bone Morphogenetic Protein-4/7 Heterodimer
- Biochem Biophys Res Commun V210 (3) p670-677, 1995
- Cook, S.D., Dalton, J.E., Tan, E.H., Whitecloud, T.S. III, and Rueger D.C.
- In
Vivo Evaluation of Recombinant Human Osteogenic Protein (rhOP-1) Implants As A Bone
Graft Substitute for Spinal Fusions
- Spine V19 (15) p1655-1663, 1994
- Malpe, R., Baylink, D.J., Sampath, T.K., and Mohan, S.
- Evidence
That Human Bone Cells in Culture Contain Binding Sites for Osteogenic Protein-1
- Biochem Biophys Res Commun V201(2) p1140-1147, June 30, 1994
-
- Dieudonne, S.C., Semeins, C.M., Goei, S.W., Vukicevic, S., Nulend, J.K., Sampath, T.K.,
Helder, M., and Burger, E.H.
- Opposite
Effects of Osteogenic Protein And Transforming Growth Factor Beta On Chondrogenesis In
Cultured Long Bone Rudiments
- Journal of Bone and Mineral Research V9 (6) p771-780, June 1994
- Cook, S.D., Baffes, G.C., Wolfe, M.W., Sampath, T.K., Rueger, D.C., and Whitecloud, T.S.
III
- The
Effect of Recombinant Human Osteogenic Protein-1 on Healing of Large Segmental Bone
Defects
- J Bone Joint Surg Am V76 (6) p827-828, June 1994
- Cook, S.D., Baffes, G.C., Wolfe, M.W., Sampath, T.K., and Rueger, D.C.
- Recombinant
Human Bone Morphogenetic Protein-7 Induces Healing in a Canine Long-bone Segmental Defect
Model
- Clin Orthop V30, p302-312, April 1994
- Chen, P., Vukicevic, S., Sampath, T.K., and Luyten, F.P.
- Bovine
Articular Chondrocytes Do Not Undergo Hypertrophy When Cultured in the Presence of Serum
and Osteogenic Protein-1
- Biochem Biophys Res Comm V197 (3) p1253-1259, December 30, 1993
- Asahina, I., Sampath, T.K., Nishimura, I., and Hauschka, P.V.
- Human
Osteogenic Protein-1 Induces Both Chondroblastic and Osteoblastic Differentiation of
Osteoprogenitor Cells Derived From Newborn Rat Calvaria
- J Cell Biol V123 (4) p921-933, November 1993
- Knutsen, R., Wergedal, J.E., Sampath, T.K., Baylink, D.J., and Mohan, S.
- Osteogenic
Protein-1 Stimulates Proliferation and Differentiation of Human Bone Cells In Vitro
- Biochem Biophys Res Comm V194 (3) p1352-1358, August 16, 1993
-
4.
Dental Applications
- McAllister, B.S., Margolin, M.D., Cogan, A.G., Taylor, M., Wollins, J.
- Residual
lateral wall defects following sinus grafting with recombinant human osteogenic protein-1
or Bio-Oss in the chimpanzee
- International Journal of Periodontics & Restorative Dentistry V.18/N.3, p.227-239,
1998
-
- Giannobile, W.V., Ryan, S., Shih, M.S., Su, D.L., Kaplan, P.L., Chan, T.C.
- Recombinant
human osteogenic protein-1 (OP-1) stimulates periodontal wound healing in class III
furcation defects
- J Periodontal (United States), 69 (2), p. 129-37, Feb. 1998.
-
- Helder, M.N., Karg, H. Bervoets, T.J.M., Vokicevic, S., Burger, E.H., D’Souza,
R.N., Woltgens, J.H.M., Karsenty, G., Bronckers, A.L.J.J.
- Bone
morphogenetic protein-7 (osteogenic protein-1, OP-1) and tooth development
- Journal of Dental Research 77 (4) p. 545-554, 1998
-
- Heikinheimo, K., BegueKirn, C., Ritvos, O., Tuuri, T., Ruch, J.V.
- Activin
and bone morphogenetic protein (BMP) signalling during tooth development
- European Journal of Oral Sciences, V106/1 (Jan), p.167-173, 1998
-
- Lee, M.B.
- Bone
Morphogenetic Proteins: Background and Implications for Oral Reconstruction
- J. Clin. Periodontal, v.24, pp. 355-365, 1997
-
- Toyono, T., Nakashima, M., Kuhara, S., Akamine, A.
- Expression
of TGF-beta superfamily receptors in dental pulp
- Journal of Dental Research, V.76/N9 (Sep), p.1555-1560, 1997
-
- Aberg, T., Wozney, J., Thesleff, I.
- Expression
patterns of bone morphogenetic proteins (BMPs) in the developing mouse tooth suggest roles
in morphogenesis and cell differentiation
- Developmental Dynamics (US), 1997, 210/4 (383-396)
-
- Terheyden, H., Jepsen S., Vogeler, S., Tucker, M., Rueger, D.C.
- Recombinant
human osteogenic protein 1 in the rat mandibular augmentation model: differences in
morphology of the newly formed bone are dependent on the type of carrier.
- Mund Kiefer GesichtsChir (Germany) V5 p 272-5 September 1997
-
- Ripamonti, U., Reddi, A.H.
- Tissue
engineering, morphogenesis, and regeneration of the periodontal tissues by bone
morphogenetic proteins
- Crit Rev Oral Biol Med (US) 8 (2), p154-63, 1997
-
- Toyono, T., Nakashima, M., Kuhara, S., Akamine, A.
- Temporal
changes in expression of tansforming growth factor-beta superfamily members and their
receptors during bovine preodontoblast differentitation in vitro
- Archives of Oral Biology, V42, N7, p481-488, July, 1997
-
- Jepsen, S., Albers, H.K., Fleiner, B., Tucker, M., Rueger, D.C.
- Recombinant
Human Osteogenic Protein-1 Induces Dentin Formation: An Experimental Study in Miniature
Swine
- Journal of Endodontics, V23 N6, p378-382, June 1997
-
- Peterkova, R., Tureckova, J., Lesot, H., Vonesch, J.L., Peterka, M., Ruch, J.V.
- Bone morphogenetic proteins (BMPs) and tooth development
- Trends in Glycoscience and Glycotechnology, V9, N47, P253-265, May 1997
-
- Jepsen, S., Albers, H-K., Erbersdobler, S., Tucker, M., and Rueger, D.
- Osteogenic Protein-1 Induces Reparative Dentin Formation
- Proceedings of the International Conference on Dentin/Pulp Complex 1995 and the
International Meeting on Clinical Topics of Dentin/Pulp Complex p321-322, Quintessence
Publishing, 1996
-
- Ripamonti ,U., Heliotis, M., Rueger D.C., and Sampath, T.K.
- Induction
of Cementogenesis by Recombinant human osteogenic protein-1 (hOP-1 BMP-7) in the baboon
(Papio ursinus)
- Arch Oral Biol V41 (1) p121-126, 1996
-
- Rutherford, B., Spangberg, L., Tucker, M., and Charette, M.
- Transdentinal
Stimulation of Reparative Dentine Formation by Osteogenic Protein-1 in Monkeys
- Archs Oral Biol (England) V40 (7) p681-683, July 1995
-
- Cook, S.D., Salkeld, S.L., and Rueger, D.C.
- Evaluation
of Recombinant Human Ostoegenic Protein-1 (rhOP-1) Placed with Dental Implants in Fresh
Extraction sites
- Journal of Oral Implantology V21 (4) p281-289, 1995
-
- Rutherford, B.R., Spangeberg, L., Tucker, M., Rueger, D.C., and Charette, M.
- The
Time-Course of the Induction of Reparative Dentine Formation in Monkeys by Recombinant
Human Osteogenic Protein-1
- Archs Oral Biol (England) V39 (10) p833-838, 1994
-
- Rutherford R.B., Wahle, J., Tucker, M., Rueger, D., and Charette, M.
- Induction
of Reparative Dentine Formation in Monkeys by Recombinant Human Osteogenic Protein-1
- Arch Oral Biol (England) V38 (7) p571-576, July 1993
-
- Rutherford, R.B, Sampath, K., Rueger, D.C., Taylor, T.D.
- Use
of Bovine Osteogenic Protein to Promote Rapid Osseointegration of Endosseous Dental
Implants
The International Journal of Oral
and Maxillofacial Implants V.7 p. 297-301, 1992
5.
Renal Applications
- Vukicevic S, Basic V, Rogic D, Basic N, Shih MS, Shepard A, Jin D, Dattatreyamurty B,
Jones W, Dorai H, Ryan S,
Griffiths D, Maliakal J, Jelic M, Pastorcic M, Stavljenic A, Sampath TK
- Osteogenic
Protein-1 (Bone Morphogenetic Protein-7) Reduces Severity of Injury After Ischemic Acute
Renal Failure in Rat
- J Clin Invest. 1998 Jul 1;102(1):202-14
-
- Vainio, S., Muller, U.
- Inductive
Tissue Interactions, Cell Signaling, and the Control of Kidney Organogenesis
- Cell, v.90, pp. 975-978, 1997
-
- Piscione, T.D., Tino, D., Yager, T.D., Gupta, I.R., Grinfeld, B., Pei, Y., Attisano, L.,
Wrana, J.L., Rosenblum, N.D.
- BMP-2
and OP-1 exert direct and opposite effects on renal branching morphogenesis
- American Journal of Physiol., v273(6/2), p F961-975, 1997
-
- Woolf, A.S., Cale, C.M.
- Roles
of growth factors in renal development
- Current Opnion in Nephrology and Hypertension (United Kingdom), 6/1 p10-14, 1997
-
- Lechner, M.S., Dressler, G.R.
- The
molecular basis of embryonic kidney development
- Mech Dev (IRELAND) 62 (2) p105-20, March, 1997
-
- Basic N.
- The
role of bone morphogenetic proteins in compensatory renal growth
- Lijec, Vjesn (CROATIA) 119 (2) p53-5, Feb, 1997
-
- Vukicevic, S., Kopp, J.B., Luyten, F.P., Sampath, T.K.
- Induction
of Nephrogenic Mesenchyme by Osteogenic Protein-1 (Bone Morphogenetic Protein-7)
- Proc Natl Acad of Sci USA 93 (17) p9021-9026, 1996
-
- Ekblom, P.
- Genetics
of Kidney Development
- Current Opinion in Nephrology and Hypertension (United Kingdom) 5/3 p282-287, 1996
-
- Ishibashi, K., Sasaki, S., Akiba, T., and Marumo, F.
- Expression
of Bone Morphogenetic Protein 7 mRNA in MDCK Cells
- Biochem Biophys Res Commun V193 (1) p235-239, May 28, 1993
-
6.
Neurology Applications
- Kawamata, R., Ren, J., Chan, T.C.K., Charette, M., Finklestein, S.
- Intracisternal
osteogenic protein-1 enhances functional recovery following focal stroke
- NeuroReport, V.9/N.7, p.1441-1445, 1998
-
- Song, Q., Mehler, M.F., Kessler, J.A.
- Bone
morphogenetic proteins induce apoptosis and growth factor dependence of cultured
sympathoadrenal progenitor cells
- Developmental Biology (United States), V.196/N.1, p. 119-127, Apr. 1, 1998
-
- Carri, N.G., Bengtsson, H., Charette, M.F., Ebendal, T.
- BMPR-II
expression and OP-1 effects in developing chicken retinal explants
- Neuroport 9 (6), p. 1097-1101, 1998
-
- Guo, X., Rueger, D., Higgins, D.
- Osteogenic
protein-1 and related bone morphogenetic proteins regulate dendritic growth and the
expression of microtubule-associated protein-2 in rat sympathetic neurons
- Neuroscience Letters 245 (3), p. 131-134, 1998
-
- Ebendal, T., Bengtsson, H., Soderstrom, S.
- Bone
morphogenetic proteins and their receptors: Potential functions in the brain
- Journal of Neuroscience Research 51 (2), p.139-146, 1998
-
- Graham, A.
- The
origin of dorsoventral patterning of the vertebrate nervous system
- Trends Genet (England), V13(12), p.463-465, Dec 1997
-
- Guo, X., Metzler-Northrup, J., Lein, P., Rueger, D.C., Higgins, D.
- Leukemia
inhibitory factor and ciliary neurotrophic factor regulate dendritic growth in cultures of
rat sympathetic neurons
- Developmental Brain Research 104 (1997), 101-110.
-
- Sharp, D.J., Yu, W., Ferhat, L., Kuriyama, R., Rueger, D.C., Baas, P.W.
- Identification
of a Microtubule-associated Motor Protein Essential for Dendritic Differentiation
- The Journal of Cell Biology, V138, N4, p833-843, August 25, 1997
-
- Lochter, A., Schachner, M.
- Inhibitors
of protein kinases abolish ECM-Mediated promotion of neuronal polarity
- Experimental Cell Research, V235, N1, p124-129, August 25, 1997
-
- Dale, J.K., Vesque, C., Lints, T.J., Sampath, T.K., Furley, A., Dodd, J., Placzek, M.
- Cooperation
of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm
- Cell (US) 90 (2), P257-69, July 25, 1997
-
- Mehler, M.F., Mabie, P.C., Zhang, D.M., Kessler, J.A.
- Bone
morphogenetic proteins in the nervous system
- Trends in Neurosciences, V20, N7, p309-317, July, 1997
-
- Lewen, A., Soderstrom, S., Hillered, L., Ebendal, T.
- Expression
of Serine/Threonine Kinase Receptors in Traumatic Brain Injury
- Neuroreport, V8 N2 p475-479, January 20, 1997
Arkell, R., Beedington, R.S.
BMP-7 Influences Pattern and Growth of the Developing
Hindbrain of Mouse Embryos
Development (ENGLAND) V124 (1) p1-12, January 1997
Heyd, B., Aebischer, P.
Neurotrophic Factors and Their Clinical Potential
J M-S (Medecine Sciences) V102 Issue 004 12 (3) p299-302, 1996
Lein, P., Guo, X., Hedges, A.M., Rueger, D.C., Johnson, M. and Higgins, D.
The
Effects of Extracellular Matrix and Osteogenic Protein-1 on the Morphological
Differentiation of Rat Sympathetic Neurons
Int J Devl Neuroscience, V14 N3 p203-215, 1996
Reissmann, E., Ernsberger, U., Francis-West, P.H., Rueger, D., Brickell, P.M., and
Rohrer, H.
Involvement
of Bone Morphogenetic Protein-4 and Bone Morphogenetic Protein-7 in the Differentiation of
the Adrenergic Phenotype in Developing Sympathetic Neurons
Development V122 p2079-2088, 1996
Varley, J.E., Wehby, R.G., Rueger, D.C., and Maxwell, G.D.
Number
of Adrenergic and Islet-1 Immunoreactive Cells is Increased in Avian Trunk Neural Crest
Cultures in the Presence of Human Recombinant Osteogenic Protein-1
Developmental Dynamics V203 (4) p434-447, 1995
Lein, P., Johnson, M., Guo, X., Rueger, D.C., and Higgins, D.
Osteogenic
Protein-1 Induces Dendritic Growth in Rat Sympathetic Neurons
Neuron V15 p597-605, 1995
Hawley, S.H., Wunnenberg-Stapleton, K., Hashimoto, C., Laurent, M.N., Watabe, T.,
Blumberg, B.W., and Cho, K.W.
Disruption
of BMP Signals in Embryonic Xenopus Ectoderm Leads to Direct Neural Induction
Genes Dev V9 (23) p2923-2935, December 1, 1995
Perides, G., Jensen, F.E., Edgecomb, P., Rueger, D.C., and Charness, M.E.
Neuroprotective
Effect of Human Osteogenic OP-1 in a Rat Model of Cerebral Hypoxial/Ischemia
Neuroscience Letters V187 (1) p21-24, February 24, 1995
Perides, G., Safran, R.M., Downing, L.A., and Charness, M.E.
Regulation
of Neural Cell Adhesion Molecule and L1 by the Transforming Growth Factor-B Superfamily. Selective
Effects of the Bone Morphogenetic Proteins
J Biol Chem V269 (1) p765-770, January 7, 1994
- Charness, M.E., Safran, R.M., and Perides, G.
- Ethanol
Inhibits Neural Cell-cell Adhesion
- J Biol Chem, V269 (12) p9304-9309, March 25, 1994
- Perides, G., Hu, G., Rueger, D.C., and Charness, M.E.
- Osteogenic
Protein-1 Regulates L1 and Neural Cell Adhesion Molecule Gene Expression in Neural Cells
- J Biol Chem V268 (33) p25197-25205, November 25, 1993
-
- Perides, G., Safran, R.M., Rueger, D.C., and Charness, M.E.
- Induction
of the Neural Cell Adhesion Molecule and Neuronal Aggregation by Osteogenic Protein-1
- Proc Natl Acad Sci V89 (21) p10326-10330, November 1, 1992
-
7. Other
BMP Applications
- Weber, K.L., Bolander, M.E., Rock, M.G., Sarkar, G.
- Evidence
for the upregulation of osteogenic protein-1 mRNA expression in musculoskeletal neoplasms
- Journal of Orthopaedic Research 16 (1), p. 8-14, 1998
- Özkaynack, E., Jin, D., Jelic, M., Vukicevic, S., Oppermann, H.
- Osteogenic
protein-1 mRNA in the uterine endometrium
- Biochemical and Biophysical Research Communications 234 (1), p242-246, 1997
- Ramanathan, R., Wilkemeyer, M.F., Mittal, B., Perides, G., and Charness, M.E.
- Alcohol
Inhibits Cell-Cell Adhesion Mediated by Human L1
- Journal of Cell Biology V133 (2) p381-390, April 1996
-
- Martinovic, S,. Latin, V., Suchanek, E., Stavljenic-Rukavina, A., Sampath, T.K., and
Vukicevic, S.
- Osteogenic
Protein-1 is Produced by Human Fetal Trophoblasts In-vivo and Regulates the
Synthesis of Chorionic-Gonadotropin and Progesterone by Trophoblasts In-Vitro
- European Journal of Clinical Chemistry and Clinical Biochemistry V34 (2) p103-109,
February 1996
-
- Solursh, M., Langille, R.M., Wood, J., and Sampath, T.K.
- Osteogenic
Protein-1 is Required for Mammalian Eye Development
- Biochem Biophys Res Commun V218 (2) p438-443, January 17, 1996
- Yamada, N., Kato, M., ten Dijke, P., Yamashita, H., Sampath, T.K., Heldin, C-H,
Miyazono, K., and Funa, K.
- Bone
Morphogenetic Protein Type IB Receptor is Progressively Expressed in Malignant Glioma
Tumors
- British Journal of Cancer V73 (5) p624-629, 1996
- Andrews, P.W., Damjanov, I., Berends, J., Kumpf, S., Zappavigna, V., Mavilio, F., and
Sampath, T.K.
- Inhibition
of Proliferation and Induction of Differentiation of Pluripotent Human Embryonal Carcinoma
Cells by Osteogenic Protein-1 (or Bone Morphogenic Protein-7)
- Laboratory Investigation V71 (2) p243-251, August 1994
- Andrews, P.W., Mavilio, F., Zappavigna, V., and Sampath, T.K.
- Growth
Inhibition and Differentiation of a Human Embryonal Carcinoma (EC) Cell Line by Osteogenic
Protein-1 (OP-1)
- Advances in the Biosciences (ENGLAND) V91, p151-152, 1994
- Lefer, A.M., Tsai, P.S., Ma, X.L., and Sampath, T.K.
- Anti-Ischaemic
and Endothelial Protective Actions of Recombinant Human Osteogenic Protein (hOP-1)
- J Mol Cell Cardiol V24 (6) p585-593, June 1992
8.
Single-Chain Antibodies
- George, A.J.T. and Huston, J.S.
- Bispecific Antibody Engineering
- The Antibodies, V.4, p.99-141, 1997
- Keck, P.C., and Huston, J.S.
- Symmetry
of Fv Architecture is Conductive to Grafting a Second Antibody Binding Site in the Fv
Region
- Biophysical Journal, p.2002-2011, 1996
-
- Huston, J.S., and Haber, E.
- An
Overview of the 1996 Keystone Meeting. Exploring and Exploiting Antibody and Ig
Superfamily Combining Sites
- Immunotechnology, p.253-260, 1996
-
- Huston, J.S., Margolies, M.M., and Haber, E.
- Antibody
Binding Sites
- Advances in Protein Chemistry, p.329-450, 1996
- McCartney, J.E., Oppermann, H., Heelan, B.T., Peters, A.M., Houston, L.L., Bookman,
M.A., Wolf, E.J., and Weiner, L.M.
- Single-Chain
Fv Radioimmunotargeting
- Quarterly Journal of Nuclear Medicine, p.320-333, 1996
- George, A.J.T., Huston, J.S., and Haber, E.
- Exploring
and Exploiting the Antibody and Ig Superfamily Combining Sites
- Nature Biotechnology, p.584, 1996
- Tai, M.S., McCartney, J.E., Adams, G.P., Jin, D., Hudziak, R.M., Oppermann, H., Laminet,
A.A., Bookman, M.A., Liu, S., Stafford III, W.F., Fand, I., Houston, L.L., Weiner, L.M.,
and Huston, J.S.
- Targeting
c-erbB-2 Expressing Tumors Using Single-Chain Fv Monomers and Dimers
- Cancer Research, p.5983s-5989s, 1995
-
- Schier, R., Marks, J.D., Wolf, E.J., Apell, G., Wong, C., McCartney, J.E., Bookman,
M.A., Huston, J.S., Houston, L.L., Weiner, L.M., and Adams, G.P.
- In
Vitro and In Vivo Characterization of a Human Anti-c-erbB-2 Single-Chain Fv
Isolated from a Filamentous Phage Antibody Library
- Immunotechnology, p.73-81, 1995
- George, A.J.T., Jamar, F., Tai, M.S., Heelan, B.T., Adams, G.P., McCartney, J.E.,
Houston, L.L., Weiner, L.M., Oppermann, H., Peters, A.M., and Huston, J.S.
- Radiometal
Labeling of Recombinant Proteins by a Genetically Engineered, Minimal Chelation Site:
Technetium-99m Coordination by Single-Chain Fv Antibody Fusion Proteins Through a
C-Terminal Cysteinyl Peptide
- Proc. Natl. Acad. Sci., p.8358-8362, 1995
- Adams, G.P., McCartney, J.E., Wolf, E.J., Eisenberg, J., Huston, J.S., Bookman, M.A.,
Moldofsky, P., Stafford III, W.F., Houston, L.L., and Weiner, L.M.
- Enhanced
Tumor Specificity with Stably Iodinated 741F8-1 (sFv')2, an Anti-c-erbB-2
Single-Chain Fv Dimer
- Journal of Nuclear Medicine, p.2276-2281, 1995
- Adams, G.P., McCartney, J.E., Wolf, E.J., Oppermann, H., Tai, M.S., Eisenberg, J.,
Giantonio, B., Schultz, J., Bookman, M.A., Laminet, A., Apell, G., Stafford III, W.F.,
Liu, S., Huston, J.S., Houston, L.L., and Weiner, L.M.
- Preclinical Studies and Optimization of Specific Tumor Delivery for 741F8
anti-c-erbB-2 Single-Chain Fv Species
- Intl. Journal of Pharmacognosy, p.75-91, 1995
- Huston, J.S.
- Reinventing the Trojan Horse of Cancer Therapy
- Tumor Targeting, p.125-127, 1995
- Adams, G.P., McCartney, J.E., Wolf, E.J., Eisenberg, J., Tai, M.S., Huston, J.S.,
Stafford III, W.F., Bookman, M.A., Houston, L.L., and Weiner, L.M.
- Optimization
of In Vivo Tumor Targeting in SCID Mice with Divalent Forms of 741F8 Anti-c-erbB-2
Single-Chain Fv: Effects of Dose Escalation and Repeated i.v. Administration
- Cancer Immunology and Immunotherapy, p.299-306, 1995
- McCartney, J.E., Tai, M.S., Hudziak, R.M., Adams, G.P., Weiner, L.M., Jin, D., Stafford
III, W.F., Liu, S., Bookman, M.A., Laminet, A.A., Fand, I., Houston, L.L., Oppermann, H.,
and Huston, J.S.
- Engineering
Disulfide-Linked Single-Chain Fv Dimers [(sFv')2] with Improved Solution and
Targeting Properties: Anti-Digoxin 26-10 (sFv')2 and Anti-c-erbB-2 741F8 (sFv')2
made by Protein Folding and Bonded through C-Terminal Cysteinyl Peptides
- Protein Engineering, p.301-314, 1995
- George, A.J.T., Titus, J.A., Jost, C.R., Kurucz, I., Perez, P., Andrew, S.M., Nicholls,
P.J., Huston, J.S., and Segal, D.M.
- Redirection
of Cellular Cytotoxicity: a Two-Step Approach Using Recombinant Single-Chain Fv Molecules
- Cell Biophysics, p.153-165, 1995
- Weiner, L.M., Houston, L.L., Huston, J.S., McCartney, J.E., Tai, M.S., Appel, G.,
Stafford III, W.F., Bookman, M.A., Gallo, J., and Adams, G.P.
- Improving the Tumor-Selective Delivery of Single-Chain Fv Molecules
- Tumor Targeting, p.51-60, 1995
- Huston, J.S., George, A.J.T., Tai, M.S., McCartney, J.E., Jin, D., Segal, D.M., and
Oppermann, H.
- Single-Chain Fv Design and Production by Preparative Folding
- Antibody Engineering, p.185-227, 1995
- Huston, J.S., Adams, G.P., McCartney, J.E., Tai, M.S., Oppermann, H., Liu, S., Stafford
III, W.F., Bookman, M.A., Fand, I., Apell, G., Laminet, A., Houston, L.L., and Weiner,
L.M.
- Tumor
Targeting in a Tumor Xenograft Model with the (sFv')2 Divalent Form of Aanti-c-erbB-2
Single-Chain Fv
- Cell Biophysics, p.249-257, 1994
- Dorai, H., McCartney, J.E., Hudziak, R.M., Tai, M.S., Laminet, A.A., Houston, L.L.,
Huston, J.S., and Oppermann, H.
- Mammalian
Cell Expression of Single-Chain Fv (sFv) Antibody Proteins and their C-Terminal Fusions
with Interleukin-2 and other Effector Domains
- Bio/Technology, p.890-897, 1994
- George, A.J.T., Titus, J.A., Jost, C.R., Kurucz, I., Perez, P., Andrew, S.M., Nicholls,
P.J., Huston, J.S., and Segal, D.M.
- Redirection
of T Cell-Mediated Cytotoxicity by a Recombinant Single-Chain Fv Molecule
- J. Immunology, p.1802-1811, 1994
- Nedelman, M.A., Shealy, D.J., Boutin , R., Brunt, E., Seasholtz, J.I., Allen I.E.,
Weisman, H.F., McCartney, J.E., Warren, F.D., Oppermann, H., Pang, R.H.L., and Berger,
H.J.
- Rapid
Infarct Imaging with a Technetium-99m Antimyosin sFv Fragment: Evaluation in a Canine
Model of Acute Myocardial Infarction
- J. Nuclear Med., p.234-241, 1993
- Huston, J.S., Tai, M.S., McCartney, J., Keck, P., and Oppermann, H.
- Antigen
Recognition and Targeted Delivery by the Single-Chain Fv
- Cell Biophysics, p.189-224, 1993
- Huston, J.S., Keck, P., Tai, M.S., Jin, D., McCartney, J., Stafford III, W.F.,
Mudgett-Hunter, M., Oppermann, H., and Haber, E.
- Single-Chain Immunotechnology of Fv Analogues and Fusion Proteins
- In Immunotechnology, p.47-60, 1993
- Adams, G.P., McCartney, J.E., Tai, M.S., Oppermann, H., Huston, J.S., Stafford III,
W.F., Bookman, M.A., Fand, I., Houston, L.L., and Weiner, L.M.
- Highly
Specific In Vivo Tumor Targeting by Monovalent and Divalent Forms of 741F8 Anti-c-erbB-2
Single-Chain Fv
- Cancer Research, p.4026-4034, 1993
- Huston, J.S., McCartney, J., Tai, M.S., Mottola-Hartshorn, C., Jin, D., Warren, F.,
Keck, P., and Oppermann, H.
- Medical
Applications of Single-Chain Antibodies
- International Reviews of Immunology, p.195-217, 1993
- McCartney, J.E., Tai, M.S., Oppermann, H., Jin, D., Warren, F.D., Weiner, L.M., Bookman,
M.A., Stafford III, W.F., Houston, L.L., and Huston, J.S.
- Refolding of Single-Chain Fv with C-Terminal Cysteine (sFv'): Formation of
Disulfide-Bonded Homodimers of Anti-c-erbB-2 and Aanti-Digoxin sFv'
- Miami Short Reports, p.91, 1993
- Huston, J.S., Cohen, C., Maratea, D., Fields, F., Tai, M.S., Cabral-Denison, N.,
Juffras, R., Rueger, D.C., Ridge, R.J., Oppermann, H., and Baird, L.G.
- Multisite
Association by Recombinant Proteins can Enhance Binding Selectivity: Preferential Removal
of Immune Complexes from Serum by Immobilized Truncated FB Analogues of the B Domain from
Staphylococcal Protein A
- Biophysical Journal, p.87-91, 1992
- McCartney, J., Lederman, L., Drier, E., Cabral-Denison, N., Wu, G.M., Batorsky, R.,
Huston, J.S., and Oppermann, H.
- Biosynthetic
Antibody Binding Sites: Development of a Single-Chain Fv Model Based on Anti-Dinitrophenol
IgA Myeloma MOPC 315
- Journal of Protein Chemistry, p.669-683, 1991
- Huston, J.S., Mudgett-Hunter, M., Tai, M.S., McCartney, J., Warren, F., Haber, E., and
Oppermann, H.
- Protein
Engineering of Single-Chain Fv Analogues and Fusion Proteins
- Methods in Enzymology, p.46-88, 1991
- Andrew, S.M., Perez, P., Nicholls, P.J., George, A.J.T., Huston, J.S., Oppermann, H.,
and Segal, D.
- Production of a Single Chain Bispecific Antibody by Recombinant DNA Technology
- Bispecific Antibodies and Targeted Cellular Cytotoxicity, Proceedings of the Second
International Conference, p.197-199
- Huston, J.S., Tai, M.S., McCartney, J., Warren, F., Mudgett-Hunter, M., Oppermann, H.
- Bifunctional Single-Chain Fv Fusion Proteins
- Bispecific Antibodies and Targeted Cellular Cytotoxicity, Proceedings of the Second
International Conference, p.201-206
- Tai, M.S., Mudgett-Hunter, M., Levinson, D., Wu, G.M., Haber, E., Oppermann, H., and
Huston, J.S.
- A
Bifunctional Fusion Protein Containing Fc-Binding Fragment B of Staphylococcal Protein A
Amino Terminal to Antidigoxin Single-Chain Fv
- Biochemistry, p.8024-8030, 1990
- McCartney, J., Lederman, L., Drier, E., Wu, G.M., Cabral-Denison, N., Huston, J.S., and
Oppermann, H.
- Biosynthetic Antibody Binding Site (BABS) Proteins: Binding Activities of MOPC
315 VH, Fv and Single-Chain Fv
- ICSU Short Reports, p.114, 1990
- Huston, J.S., Levinson, D., Mudgett-Hunter, M., Tai, M.S., Novotny, J., Margolies, M.N.,
Ridge, R.J., Bruccoleri, R.E., Haber, E., Crea, R., and Oppermann, H.
- Protein
Engineering of Antibody Binding Sites: Recovery of Specific Activity in an Anti-Digoxin
Single-Chain Fv Analogue Produced in Escherichia Coli
- Proc. Natl. Acad. Science, 5879-5883, 1988
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